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Associations between Pouchitis and Fecal Calprotectin after Restorative Proctocolectomy in Patients with Ulcerative Colitis.溃疡性结肠炎患者行结直肠切除术后储袋炎与粪便钙卫蛋白之间的关联
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2
Vedolizumab for the Treatment of Chronic Pouchitis.维得利珠单抗治疗慢性袋炎。
N Engl J Med. 2023 Mar 30;388(13):1191-1200. doi: 10.1056/NEJMoa2208450.
3
Medical management of chronic pouch inflammation.慢性储袋炎的药物治疗
Curr Res Pharmacol Drug Discov. 2022 Mar 3;3:100095. doi: 10.1016/j.crphar.2022.100095. eCollection 2022.
4
An Update on the Medical Management of Inflammatory Pouch Complications.炎症性袋并发症的医学管理更新。
Am J Gastroenterol. 2020 Sep;115(9):1439-1450. doi: 10.14309/ajg.0000000000000666.
5
Endoscopic activity in asymptomatic patients with an ileal pouch is associated with an increased risk of pouchitis.无症状的回肠贮袋患者内镜下活动与贮袋炎风险增加相关。
Aliment Pharmacol Ther. 2019 Dec;50(11-12):1189-1194. doi: 10.1111/apt.15505. Epub 2019 Oct 3.
6
Reliability among central readers in the evaluation of endoscopic disease activity in pouchitis.内镜评估 pouchitis 中中心读者间评估的可靠性。
Gastrointest Endosc. 2018 Aug;88(2):360-369.e2. doi: 10.1016/j.gie.2018.04.2330. Epub 2018 Apr 13.
7
Ileal pouch symptoms do not correlate with inflammation of the pouch.回肠袋症状与回肠袋炎症不相关。
Clin Gastroenterol Hepatol. 2014 May;12(5):831-837.e2. doi: 10.1016/j.cgh.2013.09.027. Epub 2013 Sep 27.

内镜反应可降低克罗恩病样储袋炎患者后续发生储袋炎的风险。

Endoscopic Response Reduces the Risk of Subsequent Pouchitis in Patients With Crohn's Disease-Like Pouch Inflammation.

作者信息

Kayal Maia, Posner Hannah, Jimenez Darwin, Huang Justin, Dubinsky Marla C, Colombel Jean Frederic

机构信息

Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA .

出版信息

Am J Gastroenterol. 2025 Jan 1;120(1):251-253. doi: 10.14309/ajg.0000000000003055. Epub 2024 Aug 27.

DOI:10.14309/ajg.0000000000003055
PMID:39207312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11695146/
Abstract

INTRODUCTION

The aim of this study was to report the frequency and impact of endoscopic response and remission on the risk of subsequent pouchitis in patients with Crohn's disease-like pouch inflammation (CDLPI) on therapy.

METHODS

This was a single-center retrospective study of patients older than 18 years with CDLPI on therapy.

RESULTS

Among 110 included patients with CDLPI in clinical remission, endoscopic remission was not significantly associated with a reduced risk of subsequent pouchitis when compared with endoscopic response.

DISCUSSION

Endoscopic response, not remission, is sufficient to reduce the risk of subsequent pouchitis in patients with CDLPI.

摘要

引言

本研究的目的是报告内镜反应和缓解对接受治疗的克罗恩病样袋炎（CDLPI）患者后续发生袋炎风险的频率和影响。

方法

这是一项对18岁以上接受CDLPI治疗患者的单中心回顾性研究。

结果

在110例临床缓解的CDLPI患者中，与内镜反应相比，内镜缓解与后续袋炎风险降低无显著相关性。

讨论

内镜反应而非缓解足以降低CDLPI患者后续发生袋炎的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/11695146/fdceac93c429/nihms-2018772-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/11695146/fdceac93c429/nihms-2018772-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/11695146/fdceac93c429/nihms-2018772-f0001.jpg