O'Keefe S J, Spitaels J M, Mannion G, Naiker N
S Afr Med J. 1985 Mar 2;67(9):321-4.
The effects of two dosage levels of a synthetic prostaglandin E1 analogue, misoprostol, and cimetidine on short-term duodenal ulcer healing were compared in a double-blind, endoscopically controlled 4-week study. The 66 adult patients were randomly divided into three groups, receiving either misoprostol 200 micrograms 4 times a day, misoprostol 50 micrograms 4 times a day or cimetidine 300 mg 4 times a day. Rates of healing were comparable in the three groups, with complete healing in 62% of those patients receiving cimetidine and high-dose misoprostol. Patients whose ulcers had healed were then followed up for a further 6 months in order to assess recurrence rates. Relapse rates were significantly higher in the cimetidine-treated group (85% within 6 months) than in the misoprostol-treated groups (50% in the low-dose and 38% in the high-dose group).
在一项为期4周的双盲、内镜对照研究中，比较了两种剂量水平的合成前列腺素E1类似物米索前列醇和西咪替丁对十二指肠溃疡短期愈合的影响。66例成年患者被随机分为三组，分别接受每日4次、每次200微克米索前列醇，每日4次、每次50微克米索前列醇或每日4次、每次300毫克西咪替丁治疗。三组的愈合率相当，接受西咪替丁和高剂量米索前列醇治疗的患者中62%实现了完全愈合。溃疡已愈合的患者随后又随访了6个月，以评估复发率。西咪替丁治疗组的复发率（6个月内为85%）显著高于米索前列醇治疗组（低剂量组为50%，高剂量组为38%）。
