Simjee A E, Bhoola R L, Spitaels J M, Manion G L
Department of Medicine, University of Natal, Durban.
S Afr Med J. 1988 Nov 5;74(9):446-7.
A double-blind controlled trial was undertaken to compare the relative effectiveness of pirenzepine (Gastrozepin; Boehringer Ingelheim) and cimetidine (Tagamet; SK & F) in healing endoscopically proven duodenal ulcers. Thirty patients with duodenal ulcers were treated with pirenzepine 50 mg twice daily and 30 patients with cimetidine 400 mg twice daily. Endoscopy was repeated after 4 weeks. Ulcers healed completely in 15 patients on pirenzepine and 21 patients on cimetidine (chi-square test 3.05; P less than 0.1); this difference was not significant. Treatment resulted in endoscopic improvement in 25 patients on pirenzepine and in 26 patients on cimetidine; this difference was also not statistically significant (chi-square test 1.18; P less than 0.5). No adverse effects were seen with cimetidine. Mild and reversible side-effects were seen in 4 patients on pirenzepine. The efficacy of pirenzepine appears similar to that of cimetidine in the healing of duodenal ulcers.
进行了一项双盲对照试验，以比较哌仑西平（胃仙-U；勃林格殷格翰公司）和西咪替丁（泰胃美；史克必成公司）在治疗经内镜证实的十二指肠溃疡方面的相对疗效。30例十二指肠溃疡患者每日两次服用50毫克哌仑西平，30例患者每日两次服用400毫克西咪替丁。4周后重复进行内镜检查。15例服用哌仑西平的患者和21例服用西咪替丁的患者溃疡完全愈合（卡方检验3.05；P小于0.1）；这种差异不显著。治疗使25例服用哌仑西平的患者和26例服用西咪替丁的患者内镜检查结果有所改善；这种差异也无统计学意义（卡方检验1.18；P小于0.5）。西咪替丁未见不良反应。4例服用哌仑西平的患者出现了轻微且可逆的副作用。在十二指肠溃疡的愈合方面，哌仑西平的疗效似乎与西咪替丁相似。
