Haverich A, Dawkins K D, Baldwin J C, Reitz B A, Billingham M E, Jamieson S W
Transplantation. 1985 Apr;39(4):356-60. doi: 10.1097/00007890-198504000-00003.
To investigate the long-term histologic consequences of combined heart and lung transplantation, heart and lung biopsies were obtained from six rhesus monkeys; two had undergone heart-lung autotransplantation 3.5 and 4.5 years previously, two were the recipients of heart-lung allografts 4.1 and 4.5 years previously, and the results were compared with two normal control animals. Cyclosporine had been used as maintenance immunosuppression in the allograft group. The heart and lung biopsies in the autograft animals were essentially normal. Dense adhesions were noted in the allografts, adn in one the visceral pleura was grossly thickened. Cardiac biopsies in the allografts were unimpressive, with a normal myocardium in one, and minimal interstitial fibrosis in the other. Intimal hyperplasia was present in the pulmonary arterioles of one of the allografted animals. Focal scarring was present in the lung of one allograft recipient, and the other animal showed severe thickening and fibrosis of the alveolar septae, as well as marked interstitial fibrosis such that large areas of the specimen were replaced by connective tissue. Histologic abnormalities in the allografted lungs correlated with the abnormal hemodynamics in these animals reported in a previous study. It is suggested that the histologic appearances in the lung are a consequence of chronic rejection, and that these findings may become a significant problem in human heart-lung transplant recipients.
为了研究心肺联合移植的长期组织学后果，从六只恒河猴身上获取了心肺组织活检样本；其中两只在3.5年和4.5年前接受了心肺自体移植，两只在4.1年和4.5年前接受了心肺异体移植，并将结果与两只正常对照动物进行了比较。在异体移植组中，环孢素被用作维持免疫抑制药物。自体移植动物的心肺活检基本正常。异体移植中发现有致密粘连，其中一例脏层胸膜明显增厚。异体移植的心脏活检结果不明显，一例心肌正常，另一例有轻微的间质纤维化。其中一只异体移植动物的肺小动脉存在内膜增生。一名异体移植受者的肺部有局灶性瘢痕形成，另一只动物的肺泡间隔出现严重增厚和纤维化，以及明显的间质纤维化，以至于标本的大片区域被结缔组织取代。异体移植肺的组织学异常与先前研究中报道的这些动物的异常血流动力学相关。提示肺部的组织学表现是慢性排斥反应的结果，并且这些发现可能成为人类心肺移植受者的一个重要问题。
