Reitz B A, Burton N A, Jamieson S W, Bieber C P, Pennock J L, Stinson E B, Shumway N E
J Thorac Cardiovasc Surg. 1980 Sep;80(3):360-72.
Combined heart and lung transplantation was performed in rhesus or cynomolgus monkeys in order to confirm the ability of primates to withstand complete cardiopulmonary denervation, to develop a satisfactory operative method, and to obtain survival of allotransplant recipients using Cyclosporin-A immune suppression. Twenty-seven monkeys weighing 2.6 to 10.1 kg received either autotransplants or allotransplants by two different operative techniques. Seventeen animals were operated upon with hypothermia and circulatory arrest. One autotransplant recipient is alive at 368 days, but all allotransplant recipients (untreated) died within 5 days despite normal breathing patterns. Ten animals operated upon with the aid of cardiopulmonary bypass fared better. Three autotransplant recipients are alive 60, 199, and 312 days postoperatively. Three of seven allotransplant recipients treated with Cyclosporin-A (25 mg/kg, then tapered) and azathioprine (2 mg/kg for 14 days) were long-term survivors. One died at 144 days of lymphoma and two are currently living 156 and 191 days postoperatively. The results suggest that heart and lung transplantation is possible in primates and that allografted recipients can survive for extended periods with Cyclosporin-A used for immune suppression.
在恒河猴或食蟹猴身上进行心肺联合移植，以确认灵长类动物耐受完全心肺去神经支配的能力、开发一种令人满意的手术方法，并使用环孢素A免疫抑制使同种异体移植受者存活。27只体重在2.6至10.1千克之间的猴子通过两种不同的手术技术接受了自体移植或同种异体移植。17只动物在低温和循环停止的情况下接受了手术。一名自体移植受者在368天时存活，但所有同种异体移植受者（未治疗）尽管呼吸模式正常，仍在5天内死亡。借助体外循环进行手术的10只动物情况较好。三名自体移植受者在术后60、199和312天存活。七名接受环孢素A（25毫克/千克，然后逐渐减量）和硫唑嘌呤（2毫克/千克，持续14天）治疗的同种异体移植受者中有三名是长期存活者。一名在144天时死于淋巴瘤，两名目前分别在术后156天和191天存活。结果表明，灵长类动物可行心肺移植，并且使用环孢素A进行免疫抑制时，同种异体移植受者可以长期存活。
