Department of Medical Imaging, Medical School, University of Pecs, Pecs, Hungary.
Department of Radiology and Medical Imaging, Mures County Emergency Clinical Hospital of Targu Mures, Targu Mures, Romania.
PLoS One. 2024 Aug 29;19(8):e0309563. doi: 10.1371/journal.pone.0309563. eCollection 2024.
Resting-state functional magnetic resonance imaging (rs-fMRI) has been widely utilized to investigate plasticity mechanisms and functional reorganization in multiple sclerosis (MS). Among many resting state (RS) networks, a significant role is played by the salience network (SN, ventral attention network). Previous reports have demonstrated the involvement of osteopontin (OPN) in the pathogenesis of MS, which acts as a proinflammatory cytokine ultimately leading to neurodegeneration. Concentration of serum OPN was related to MRI findings 10.22±2.84 years later in 44 patients with MS. Local and interhemispheric correlations (LCOR, IHC), ROI-to-ROI and seed-based connectivity analyses were performed using serum OPN levels as independent variable along with age and gender as nuisance variables. We found significant associations between OPN levels and local correlation in right and left clusters encompassing the central opercular- and insular cortices (p-FDR = 0.0018 and p-FDR = 0.0205, respectively). Moreover, a significant association was identified between OPN concentration and interhemispheric correlation between central opercular- and insular cortices (p-FDR = 0.00015). Significant positive associations were found between OPN concentration and functional connectivity (FC) within the SN (FC strength between the anterior insula ventral division and 3 other insular regions, F(2,13) = 7.84, p-FDR = 0.0117). Seed-based connectivity analysis using the seven nodes of the SN resulted in several positive and inverse associations with OPN level. Serum OPN level may predict FC alterations within the SN in 10 years.
静息态功能磁共振成像（rs-fMRI）已广泛用于研究多发性硬化症（MS）中的可塑性机制和功能重组。在众多静息态（RS）网络中，突显网络（SN，腹侧注意网络）起着重要作用。先前的报告表明骨桥蛋白（OPN）在 MS 的发病机制中起作用，OPN 作为一种促炎细胞因子，最终导致神经退行性变。44 例 MS 患者的血清 OPN 浓度与 MRI 发现 10.22±2.84 年后有关。使用血清 OPN 水平作为独立变量，年龄和性别作为干扰变量，进行局部和半球间相关性（LCOR，IHC）、ROI-ROI 和种子连接分析。我们发现 OPN 水平与包含中央脑岛和岛盖皮质的右和左聚类中的局部相关性之间存在显著相关性（p-FDR = 0.0018 和 p-FDR = 0.0205）。此外，还发现中央脑岛和岛盖皮质之间的半球间相关性与 OPN 浓度之间存在显著相关性（p-FDR = 0.00015）。还发现 OPN 浓度与 SN 内功能连接（FC）之间存在显著正相关（前岛叶腹侧部与其他 3 个岛叶区域之间的 FC 强度，F（2,13）=7.84，p-FDR = 0.0117）。使用 SN 的 7 个节点进行的基于种子的连接分析导致与 OPN 水平存在几个正相关和负相关。血清 OPN 水平可能预测 10 年内 SN 内 FC 的改变。
