Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Folia Parasitol (Praha). 2023 Feb 1;70:2023.004. doi: 10.14411/fp.2023.004.
It is estimated that nearly one-third of the world's human population is infected with Toxoplasma gondii (Nicolle et Manceaux, 1908). Human infection is commonly asymptomatic, multifaceted, and can manifest in severe pathological forms in congenital toxoplasmosis and immunocompromised individuals. This study attempted to recognise the seroprevalence of T. gondii infection in Iranian residents referred to medical laboratories for toxoplasmosis tests throughout the country. This retrospective cross-sectional study was conducted from 2015 to 2019 on individuals referred to diagnostic laboratories in 26 provinces, and these laboratories sent their samples to the referral centres. Accordingly, data associated with serodiagnosis of toxoplasmosis, age, sex, anti-T. gondii IgG, and IgM status in Iranian residents were collected from two referral diagnostic laboratories. All individuals were evaluated using the antibody immunocapture-chemiluminescence assay (CLIA) method with the Immulite2000s XPi system. In this study, the first large-scale assay of T. gondii infection in Iran, an overall seroprevalence of 30.4% was among 35,047 patients examined. The highest IgM seropositivity rate was in the 10-20 years old patients. In addition, this study showed a very different prevalence of T. gondii across the country, highest in the humid areas, such as the Caspian Sea basin in the North, and the North West with seroprevalence of 48.6%.
据估计，全世界近三分之一的人口感染了刚地弓形虫（Nicolle et Manceaux，1908）。人类感染通常无症状，多方面，并且在先天性弓形虫病和免疫功能低下者中可能表现为严重的病理形式。本研究试图在全国范围内，对送往医学实验室进行弓形虫病检测的伊朗居民进行 T. gondii 感染血清流行率的识别。这项回顾性横断面研究于 2015 年至 2019 年在全国 26 个省的诊断实验室中进行，这些实验室将其样本送到转诊中心。因此，从两个转诊诊断实验室收集了与伊朗居民的弓形虫病血清学诊断、年龄、性别、抗 T. gondii IgG 和 IgM 状态相关的数据。所有个体均使用抗体免疫捕获化学发光法（CLIA）方法和 Immulite2000s XPi 系统进行评估。在本研究中，首次对伊朗的 T. gondii 感染进行了大规模检测，在 35047 名受检者中，总血清阳性率为 30.4%。IgM 血清阳性率最高的是 10-20 岁的患者。此外，本研究还表明，全国各地的 T. gondii 感染流行率存在很大差异，在北部的里海盆地和西北部等潮湿地区的流行率最高，为 48.6%。
