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基于醇溶蛋白的蛋白质稳定的 Pickering 乳液作为生物活性化合物的新型载体。

Pickering emulsions stabilized by prolamin-based proteins as innovative carriers of bioactive compounds.

机构信息

Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Istanbul, Turkey.

Shiraz Pharmaceutical Products Technology Incubator, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Adv Colloid Interface Sci. 2024 Nov;333:103246. doi: 10.1016/j.cis.2024.103246. Epub 2024 Jul 5.

DOI:10.1016/j.cis.2024.103246
PMID:39208623
Abstract

Pickering emulsions (PEs) can be used as efficient carriers for encapsulation and controlled release of different bioactive compounds. Recent research has revealed the potential of prolamins in development of nanoparticle- and emulsion-based carriers which can improve the stability and bioavailability of bioactive compounds. Prolamin-based particles have been effectively used as stabilizers of various PEs including single PEs, high internal phase PEs, multiple PEs, novel triphasic PEs, and PE gels due to their tunable self-assembly behaviors. Prolamin particles can be fabricated via different techniques including anti-solvent precipitation, dissolution followed by pH adjustment, heating, and ion induced aggregation. Particles fabricated from prolamins alone or in combination with other hydrocolloids or polyphenols have also been used for stabilization of different PEs which were shown to be effective carriers for food bioactives, providing improved stability and functionality. This article covers the recent advances in various PEs stabilized by prolamin particles as innovative carriers for bioactive ingredients. Strategies applied for fabrication of prolamin particles and prolamin-based carriers are discussed. Emerging techno-functional applications of prolamin-based PEs and possible challenges are also highlighted.

摘要

Pickering 乳液 (PEs) 可用作封装和控制释放不同生物活性化合物的有效载体。最近的研究揭示了醇溶蛋白在开发纳米粒子和乳液载体方面的潜力,这些载体可以提高生物活性化合物的稳定性和生物利用度。由于醇溶蛋白具有可调节的自组装行为,因此其基于醇溶蛋白的颗粒已被有效地用作各种 PEs 的稳定剂,包括单 PEs、高内相 PEs、多 PEs、新型三相 PEs 和 PE 凝胶。醇溶蛋白颗粒可通过不同技术制备,包括反溶剂沉淀、溶解后 pH 调节、加热和离子诱导聚集。单独使用醇溶蛋白或与其他水胶体或多酚组合制备的颗粒也已用于稳定不同的 PEs,这些 PEs 被证明是食品生物活性物质的有效载体,提供了改善的稳定性和功能。本文综述了近年来通过醇溶蛋白颗粒稳定的各种 PEs 作为生物活性成分的创新载体的最新进展。讨论了用于制备醇溶蛋白颗粒和醇溶蛋白基载体的策略。还强调了醇溶蛋白基 PEs 的新兴技术功能应用和可能存在的挑战。

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