Department of Ophthalmology and Visual Sciences, Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Department of Ophthalmology and Visual Sciences, Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; BioInspired Institute, Syracuse University, Syracuse, NY 13244, USA; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.
Vision Res. 2024 Nov;224:108477. doi: 10.1016/j.visres.2024.108477. Epub 2024 Aug 28.
This focused review highlights the importance of yes-associated protein (YAP)/transcriptional coactivator with PDZ binding motif (TAZ) mechanosignaling in human trabecular meshwork and Schlemm's canal cells in response to glaucoma-associated extracellular matrix stiffening and cyclic mechanical stretch, as well as biochemical pathway modulators (with signaling crosstalk) including transforming growth factor beta 2, glucocorticoids, Wnt, lysophosphatidic acid, vascular endothelial growth factor, and oxidative stress. We provide a comprehensive overview of relevant literature from the last decade, highlight intriguing research avenues with translational potential, and close with an outlook on future directions.
这篇重点综述强调了 yes 相关蛋白 (YAP)/含 PDZ 结合基序的转录共激活因子 (TAZ) 机械信号转导在人眼小梁网和施莱姆氏管细胞中的重要性，以应对与青光眼相关的细胞外基质变硬和周期性机械拉伸，以及包括转化生长因子 β2、糖皮质激素、Wnt、溶血磷脂酸、血管内皮生长因子和氧化应激在内的生化途径调节剂（具有信号串扰）。我们提供了过去十年相关文献的综合概述，突出了具有转化潜力的有趣研究途径，并展望了未来的方向。
