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免疫功能正常成人中出现严重麻疹合并肺炎。

Severe measles with pneumonitis in an immunocompetent adult.

机构信息

King's College Hospital NHS Foundation Trust, London, United Kingdom.

King's College Hospital NHS Foundation Trust, London, United Kingdom.

出版信息

Clin Med (Lond). 2024 Sep;24(5):100239. doi: 10.1016/j.clinme.2024.100239. Epub 2024 Aug 30.

DOI:10.1016/j.clinme.2024.100239
PMID:39208983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11415568/
Abstract

Measles is a highly contagious but vaccine-preventable airborne-transmitted viral infection of which there has been a recent resurgence of cases worldwide over the past year, including in countries such as the UK, which had previously successfully achieved endemic measles elimination through vaccination programmes. Measles is typically a self-limiting illness, but can rarely cause severe, life-threatening disease, particularly when complicated by respiratory or neurological involvement. These severe complications are not typically seen in the absence of immunosuppression. We describe a rare case of severe measles with pneumonitis in an immunocompetent adult necessitating admission to an intensive care unit (ICU).

摘要

麻疹是一种高度传染性但可通过疫苗预防的空气传播病毒感染,在过去一年中,包括英国在内的许多国家都出现了病例的近期复燃,英国此前曾通过疫苗接种项目成功实现了麻疹的地方性消除。麻疹通常是一种自限性疾病,但很少会导致严重的、危及生命的疾病,特别是当涉及到呼吸道或神经系统并发症时。这些严重的并发症在没有免疫抑制的情况下通常不会出现。我们描述了一例免疫功能正常的成人中罕见的严重麻疹合并肺炎,需要入住重症监护病房(ICU)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/323b/11415568/9e45e65ca43d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/323b/11415568/ffca0266c84b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/323b/11415568/9e45e65ca43d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/323b/11415568/ffca0266c84b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/323b/11415568/9e45e65ca43d/gr2.jpg

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引用本文的文献

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Pandemics are here to stay: It's time for unity, both nationally and globally, in how we learn and respond.大流行将长期存在:无论是在国内还是全球,我们在学习和应对方式上都该团结起来了。
Clin Med (Lond). 2024 Sep;24(5):100244. doi: 10.1016/j.clinme.2024.100244.

本文引用的文献

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Med Sci Monit. 2024 Mar 13;30:e944436. doi: 10.12659/MSM.944436.
2
Breakthrough Infections: A Challenge towards Measles Elimination?突破性感染:对消除麻疹的挑战?
Microorganisms. 2022 Aug 4;10(8):1567. doi: 10.3390/microorganisms10081567.
3
Measles.麻疹。
Lancet. 2022 Feb 12;399(10325):678-690. doi: 10.1016/S0140-6736(21)02004-3. Epub 2022 Jan 28.
4
Measles pneumonitis.麻疹肺炎
Adv Respir Med. 2019;87(1):63-67. doi: 10.5603/ARM.a2019.0010. Epub 2019 Mar 4.
5
Case report: Ribavirin and vitamin A in a severe case of measles.病例报告:利巴韦林与维生素A治疗重症麻疹一例
Medicine (Baltimore). 2017 Dec;96(50):e9154. doi: 10.1097/MD.0000000000009154.
6
The Ribavirin Pregnancy Registry: An Interim Analysis of Potential Teratogenicity at the Mid-Point of Enrollment.利巴韦林妊娠登记处:注册中期对潜在致畸性的中期分析。
Drug Saf. 2017 Dec;40(12):1205-1218. doi: 10.1007/s40264-017-0566-6.
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Vaccines for measles, mumps and rubella in children.儿童麻疹、腮腺炎和风疹疫苗。
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