4thDepartment of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, 12462, Greece.
1stDepartment of Internal Medicine, Thriasio General Hospital, Elefsis, 19600, Greece.
J Clin Virol. 2020 Oct;131:104608. doi: 10.1016/j.jcv.2020.104608. Epub 2020 Aug 26.
Measles outbreaks are increasingly reported among countries that were close-to-eliminate measles infection. There are few reports of clinical characteristics of measles in adults in the contemporary literature. In this study we aim to describe the clinical characteristics and complications of measles infection in hospitalized adults during the recent epidemic in Greece.
A multicentre observational retrospective study was conducted in three tertiary hospitals in Greece. All adult hospitalized patients (≥18 years old) with serologically confirmed and/or clinical features compatible with measles were included. Pediatric patients and patients with missing data were excluded.
In total, 93 patients, 40 males (43 %) and 53 females (57 %), mostly young patients were included. Most of them (87 %) had no past medical history. Among women, 4 were pregnant. 56 (60.2 %) and 25 (26.9 %) patients reported either unknown or incomplete vaccination for measles. Ribavirin was administered in 8 (8.6 %) patients. Pneumonitis and hepatic involvement were the most common complications, occurring in 43 (46.2 %) and 75 (80.6 %) patients respectively. Pneumonitis was significantly associated with male sex, older age, lower lymphocyte counts and higher C-reactive protein (CRP) on admission. One pregnant woman suffered spontaneous fetal miscarriage and one patient died due to acute respiratory distress syndrome (ARDS) and high-risk pulmonary embolism.
Considerable proportions of incompletely vaccinated or unvaccinated adults have led to the re-emergence of measles in countries with reported close-to-elimination rates. Pneumonitis is a major complication among adults with measles. More studies are imperative in order to explore the role of immune paresis in measles.
在接近消除麻疹感染的国家，麻疹爆发的报道越来越多。在当代文献中，关于成年人麻疹的临床特征的报道很少。本研究旨在描述希腊最近麻疹流行期间住院成人麻疹感染的临床特征和并发症。
在希腊的三家三级医院进行了一项多中心观察性回顾性研究。所有经血清学证实和/或临床特征与麻疹相符的住院成年患者（≥18 岁）均纳入研究。排除儿科患者和数据缺失患者。
共纳入 93 例患者，其中男性 40 例（43%），女性 53 例（57%），多为年轻患者。他们中的大多数（87%）既往无病史。其中 4 例女性患者处于妊娠状态。56 例（60.2%）和 25 例（26.9%）患者报告麻疹疫苗接种情况不详或不完全。8 例（8.6%）患者接受利巴韦林治疗。肺炎和肝受累是最常见的并发症，分别发生在 43 例（46.2%）和 75 例（80.6%）患者中。肺炎与男性、年龄较大、入院时淋巴细胞计数较低和 C 反应蛋白（CRP）较高显著相关。1 例孕妇发生自发性胎儿流产，1 例患者因急性呼吸窘迫综合征（ARDS）和高危肺栓塞死亡。
在已报告接近消除率的国家，大量未完全或未接种疫苗的成年人导致麻疹再次出现。肺炎是麻疹成人患者的主要并发症。为了探索免疫功能障碍在麻疹中的作用，还需要更多的研究。
Zotero 插件