Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Institute of Medical Biophysics, Mala Hora 4, Martin 03601, Slovakia.
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Institute of Medical Biophysics, Mala Hora 4, Martin 03601, Slovakia.
Respir Physiol Neurobiol. 2024 Dec;330:104326. doi: 10.1016/j.resp.2024.104326. Epub 2024 Aug 28.
Codeine was microinjected into the area of the Kölliker-Fuse nucleus and the adjacent lateral parabrachial nucleus, within the pontine respiratory group in 8 anesthetized cats. Electromyograms (EMGs) of the diaphragm (DIA) and abdominal muscles (ABD), esophageal pressures (EP), and blood pressure were recorded and analyzed during mechanically induced tracheobronchial cough. Unilateral microinjections of 3.3 mM codeine (3 injections, each 37 ± 1.2 nl) had no significant effect on the cough number. However, the amplitudes of the cough ABD EMG, expiratory EP and, to a lesser extent, DIA EMG were significantly reduced. There were no significant changes in the temporal parameters of the cough. Control microinjections of artificial cerebrospinal fluid in 6 cats did not show a significant effect on cough data compared to those after codeine microinjections. Codeine-sensitive neurons in the rostral dorsolateral pons contribute to controlling cough motor output, likely through the central pattern generator of cough.
在 8 只麻醉猫的桥脑呼吸组内，将可待因微量注射到 Kölliker-Fuse 核和相邻的外侧臂旁核区域内。在机械诱发的气管支气管咳嗽期间，记录并分析膈（DIA）和腹肌（ABD）的肌电图（EMG）、食管压力（EP）和血压。单侧微量注射 3.3mM 可待因（3 次注射，每次 37 ± 1.2nl）对咳嗽次数没有显著影响。然而，咳嗽 ABD EMG、呼气 EP 的幅度以及膈 EMG 的幅度在较小程度上显著降低。咳嗽的时间参数没有明显变化。与可待因微量注射后相比，在 6 只猫中进行的人工脑脊液对照微量注射对咳嗽数据没有显示出显著影响。桥脑背外侧的 rostral 区域中的可待因敏感神经元有助于控制咳嗽运动输出，可能通过咳嗽的中枢模式发生器。
