Vecilla C, Bernacer M, Outeiriño J, Hernández A, Sánchez-Fayos J
An Esp Pediatr. 1985 Jan;22(1):43-7.
We report a clinical hematologic sequential process consisting of transient marrow aplasia post-hepatitis (non A-non B) preceding acute lymphoblastic leukemia. There have not been other reports mentioning a similar evolution. Authors outline the possible pathogenetic mechanisms involved in the sequence of events described. We suggest that viral infection produces a lesion of the stem-cell which could have different expressions depending on the stages of the disease at which it is studied. Those varied expressions perhaps could be explained by the modulation induced by the host's immunologic system.
我们报告了一个临床血液学连续过程，该过程包括在急性淋巴细胞白血病之前出现的肝炎（非甲非乙型）后短暂性骨髓再生障碍。尚无其他报告提及类似的演变过程。作者概述了所描述事件序列中可能涉及的致病机制。我们认为病毒感染会导致干细胞损伤，根据研究该疾病的阶段不同，其可能有不同的表现形式。这些不同的表现形式或许可以通过宿主免疫系统诱导的调节作用来解释。
