Shannon K, Koehne W, Heyman M B, Koerper M A
Department of Pediatrics, University of California School of Medicine, San Francisco 94143-0106.
Clin Pediatr (Phila). 1990 Jan;29(1):25-9. doi: 10.1177/000992289002900103.
A 20-month-old Hispanic male developed severe aplastic anemia after an episode of non-A, non-B hepatitis. Prompt and complete recovery of all hematopoietic cell lines occurred after treatment with antithymocyte globulin (ATG) and high-dose corticosteroids. Severe aplasia recurred two months later coincident with a mild upper respiratory infection. A second course of immunosuppressive therapy was followed by complete, sustained improvement. The authors' experience provides clinical evidence indicating that immunologic mechanisms are important in the treatment of severe post-hepatitis aplastic anemia. Children in whom aplastic anemia recurs after immunosuppressive treatment may respond to a second course of therapy.
一名20个月大的西班牙裔男性在患非甲非乙型肝炎后发生了严重再生障碍性贫血。在用抗胸腺细胞球蛋白（ATG）和大剂量皮质类固醇治疗后，所有造血细胞系迅速且完全恢复。两个月后，严重再生障碍再次出现，同时伴有轻度上呼吸道感染。再次进行免疫抑制治疗后，病情完全且持续改善。作者的经验提供了临床证据，表明免疫机制在严重肝炎后再生障碍性贫血的治疗中很重要。免疫抑制治疗后再生障碍性贫血复发的儿童可能对再次治疗有反应。
