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评估低危宫颈癌的微创单纯子宫切除术:LASH 试验的设定。

Assessing minimally invasive simple hysterectomy in low risk cervical cancer: set up for the LASH trial.

机构信息

UOC Ginecologia Oncologica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

出版信息

Int J Gynecol Cancer. 2024 Nov 4;34(11):1805-1808. doi: 10.1136/ijgc-2024-005941.

DOI:10.1136/ijgc-2024-005941
PMID:39209433
Abstract

After the publication of the Laparoscopic Approach to Cervical Cancer (LACC) trial, open surgery has become the standard approach for radical hysterectomy in early stage cervical cancer. Recent studies assessed the role of a non-radical approach in low risk cervical cancer and showed no survival difference compared with radical hysterectomy. However, there is a gap in knowledge regarding the oncologic outcomes of minimally invasive simple hysterectomy in low risk cervical cancer. This review offers an overview of the current evidence on the role of the minimally invasive approach in low risk cervical cancer and raises the need for a new clinical trial in this setting.

摘要

LACC 试验发表后,开放式手术已成为早期宫颈癌根治性子宫切除术的标准方法。最近的研究评估了非根治性方法在低危宫颈癌中的作用,与根治性子宫切除术相比,没有生存差异。然而,对于微创单纯子宫切除术在低危宫颈癌中的肿瘤学结果,知识上仍存在差距。本综述概述了微创方法在低危宫颈癌中的作用的现有证据,并提出了在这一背景下开展新临床试验的必要性。

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Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer.对局部晚期宫颈癌女性患者进行子宫切除术并辅以放疗或化疗或两者联合治疗。
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Front Surg. 2025 Mar 19;12:1587048. doi: 10.3389/fsurg.2025.1587048. eCollection 2025.

本文引用的文献

1
Outcomes of Radical Hysterectomy for Early-Stage Cervical Carcinoma, with or without Prior Cervical Excision Procedure.早期宫颈癌根治性子宫切除术的结局,无论是否进行过先前的宫颈切除术。
Cancers (Basel). 2024 May 29;16(11):2051. doi: 10.3390/cancers16112051.
2
LACC Trial: Final Analysis on Overall Survival Comparing Open Versus Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer.LACC 试验:早期宫颈癌开腹与微创根治性子宫切除术的总生存比较的最终分析。
J Clin Oncol. 2024 Aug 10;42(23):2741-2746. doi: 10.1200/JCO.23.02335. Epub 2024 May 29.
3
Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer.
低危型宫颈癌患者行简化根治性子宫切除术与根治性子宫切除术的比较。
N Engl J Med. 2024 Feb 29;390(9):819-829. doi: 10.1056/NEJMoa2308900.
4
ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer - Update 2023.ESGO/ESTRO/ESP 宫颈癌管理指南-2023 年更新版。
Int J Gynecol Cancer. 2023 May 1;33(5):649-666. doi: 10.1136/ijgc-2023-004429.
5
Proof-of-concept randomized phase II non-inferiority trial of simple versus type B2 hysterectomy in early-stage cervical cancer ≤2 cm (LESSER).早期≤2cm 宫颈癌(LESSER)简单型与 B2 型子宫切除术的概念验证随机Ⅱ期非劣效性试验。
Int J Gynecol Cancer. 2023 Apr 3;33(4):498-503. doi: 10.1136/ijgc-2022-004092.
6
SUCCOR cone study: conization before radical hysterectomy.SUCCOR 锥形研究:根治性子宫切除术前行锥形切除术。
Int J Gynecol Cancer. 2022 Feb;32(2):117-124. doi: 10.1136/ijgc-2021-002544. Epub 2022 Jan 17.
7
ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer.ConCerv:低危早期宫颈癌保守性手术的前瞻性研究。
Int J Gynecol Cancer. 2021 Oct;31(10):1317-1325. doi: 10.1136/ijgc-2021-002921. Epub 2021 Sep 7.
8
Protective Role of Conization Before Radical Hysterectomy in Early-Stage Cervical Cancer: A Propensity-Score Matching Study.锥切术在前瞻性宫颈癌根治术前的保护作用:倾向评分匹配研究。
Ann Surg Oncol. 2021 Jul;28(7):3585-3594. doi: 10.1245/s10434-021-09695-4. Epub 2021 Feb 23.
9
Investigating the possible impact of peritoneal tumor exposure amongst women with early stage cervical cancer treated with minimally invasive approach.探讨接受微创治疗的早期宫颈癌女性腹膜肿瘤暴露的可能影响。
Eur J Surg Oncol. 2021 May;47(5):1090-1097. doi: 10.1016/j.ejso.2020.09.038. Epub 2020 Oct 3.
10
SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer.SUCCOR 研究:一项国际欧洲队列观察性研究,比较了微创与开腹根治性子宫切除术治疗 IB1 期宫颈癌患者的效果。
Int J Gynecol Cancer. 2020 Sep;30(9):1269-1277. doi: 10.1136/ijgc-2020-001506. Epub 2020 Aug 11.