Department of Pharmacy, Hebei Medical University Third Hospital, Shijiazhuang, 050051, China.
Department of Nutrition, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050010, China.
Sci Rep. 2024 Aug 29;14(1):20122. doi: 10.1038/s41598-024-71015-z.
This study aimed to explore physicians' and pharmacists' knowledge, attitudes, and practice (KAP) regarding the prevention and treatment of cardiovascular toxicity associated with cancer treatment. A multicenter cross-sectional study included physicians and pharmacists between April 2023 and June 2023. The study included 918 participants (514 physicians and 404 pharmacists). The average scores of knowledge, attitudes, and practice were 11.6 ± 3.39, 24.7 ± 2.6, and 26.3 ± 6.8 points. Sufficient knowledge was significantly associated with age ≥ 41 years (odds ratio (OR) = 2.745, 95% confidence interval (CI) 1.086-6.941, P = 0.033), male (OR = 2.745, 95% CI 1.150-2.223, P = 0.005), bachelor's degree (OR = 0.084, 95% CI 0.013-0.533, P = 0.009), master's degree and above (OR = 0.096, 95% CI 0.015-0.609, P = 0.013), physician occupation (OR = 7.601, 95% CI 1.337-43.207, P = 0.022), pharmacy department (OR = 18.858, 95% CI 3.245-109.57, P = 0.001), oncology department (OR = 4.304, 95% CI 2.426-7.634, P < 0.001), cardiology department (OR = 3.001, 95% CI 1.387-6.492, P = 0.005), hospitals located in Eastern China (OR = 1.957, 95% CI 1.120-3.418, P = 0.018), and hospitals located in Western China (OR = 3.137, 95% CI 1.783-5.518, P < 0.001). Positive attitudes were significantly associated with a senior professional title (OR = 2.989, 95% CI 1.124-7.954, P = 0.028) and hospitals located in Eastern China (OR = 0.424, 95% CI 0.257-0.698, P = 0.001), Western China (OR = 0.231, 95% CI 0.136-0.394, P < 0.001), and Southern China (OR = 0.341, 95% CI 0.198-0.587, P < 0.001). Proactive practice was significantly associated with male (OR = 1.414, 95% CI 1.029-1.943, P = 0.033), senior professional title (OR = 3.838, 95% CI 1.176-12.524, P = 0.026), oncology department (OR = 3.827, 95% CI 2.336-6.272, P < 0.001), and cardiology department (OR = 2.428, 95% CI 1.263-4.669, P = 0.008). Both physicians and pharmacists had positive attitudes toward the prevention and treatment of cardiovascular toxicity associated with cancer treatment, while their knowledge and practice were not as proactive.
本研究旨在探讨医生和药剂师在预防和治疗癌症治疗相关心血管毒性方面的知识、态度和实践（KAP）。一项多中心横断面研究纳入了 2023 年 4 月至 6 月期间的医生和药剂师。研究共纳入 918 名参与者（514 名医生和 404 名药剂师）。知识、态度和实践的平均得分分别为 11.6±3.39、24.7±2.6 和 26.3±6.8 分。充足的知识与年龄≥41 岁（优势比（OR）=2.745，95%置信区间（CI）1.086-6.941，P=0.033）、男性（OR=2.745，95%CI 1.150-2.223，P=0.005）、学士学位（OR=0.084，95%CI 0.013-0.533，P=0.009）、硕士及以上学位（OR=0.096，95%CI 0.015-0.609，P=0.013）、医生职业（OR=7.601，95%CI 1.337-43.207，P=0.022）、药剂科（OR=18.858，95%CI 3.245-109.57，P=0.001）、肿瘤科（OR=4.304，95%CI 2.426-7.634，P<0.001）、心内科（OR=3.001，95%CI 1.387-6.492，P=0.005）、东部地区医院（OR=1.957，95%CI 1.120-3.418，P=0.018）和西部地区医院（OR=3.137，95%CI 1.783-5.518，P<0.001）显著相关。积极的态度与高级职称（OR=2.989，95%CI 1.124-7.954，P=0.028）和东部地区医院（OR=0.424，95%CI 0.257-0.698，P=0.001）、西部地区医院（OR=0.231，95%CI 0.136-0.394，P<0.001）和南部地区医院（OR=0.341，95%CI 0.198-0.587，P<0.001）显著相关。积极的实践与男性（OR=1.414，95%CI 1.029-1.943，P=0.033）、高级职称（OR=3.838，95%CI 1.176-12.524，P=0.026）、肿瘤科（OR=3.827，95%CI 2.336-6.272，P<0.001）和心内科（OR=2.428，95%CI 1.263-4.669，P=0.008）显著相关。医生和药剂师对癌症治疗相关心血管毒性的预防和治疗均持积极态度，但他们的知识和实践并不积极。
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