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醋酸甲地孕酮对大白鼠子宫的影响：组织学、组织化学和超微结构研究。

The effect of Norethisterone acetate on the uterus of albino rats: histological, histochemical and ultrastructure study.

机构信息

Department of Cell and Tissues, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia.

出版信息

BMC Vet Res. 2024 Aug 29;20(1):384. doi: 10.1186/s12917-024-04219-0.

DOI:10.1186/s12917-024-04219-0
PMID:39210341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11360500/
Abstract

BACKGROUND

Norethisterone acetate (NETA), also known as norethindrone acetate is a progestogens medication that is widely used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders as abnormal uterine bleeding and endometriosis. There is a lack of detailed histological information regarding the effects of NETA on the uterine structure. So, the present study focuses on the uterine histological, histochemical and ultrastructure changes following the exposure to NETA in the albino rats. To do this aim, fourteen adult female albino rats were used. They were randomly divided into two equally groups: Control group and NETA treated group. Albino rats of control group were administered daily food, water and orally distilled water only, while rats of NETA treated group were administered daily orally 20 µg of NETA dissolved in 2 ml distilled water, food, and water. The experiment was continued for three weeks.

RESULTS

The findings of the present work indicated that the use of NETA has negative effects on the endometrial epithelium (proliferation, autophagy and apoptosis), glands (necrotic, apoptotic or pseudosecretory glands) and stromal and myometrial reactions (granulocytes, connective tissue remodeling, apoptosis, myocytes hypertrophy).

CONCLUSION

This work revealed that NETA has desynchronized progestogenic effect on the uterine tissues of the albino rat and thereby prevent implantation and pregnancy.

摘要

背景

醋酸炔诺酮（NETA），也称为醋酸炔诺酮，是一种孕激素药物，广泛用于避孕药、更年期激素疗法以及治疗妇科疾病，如异常子宫出血和子宫内膜异位症。关于 NETA 对子宫结构的影响缺乏详细的组织学信息。因此，本研究专注于研究暴露于 NETA 后白化大鼠的子宫组织学、组织化学和超微结构变化。为此，使用了 14 只成年雌性白化大鼠。它们被随机分为两组：对照组和 NETA 处理组。对照组的白化大鼠每天给予食物、水和口服蒸馏水，而 NETA 处理组的大鼠每天口服 20µg 溶解在 2ml 蒸馏水中的 NETA、食物和水。实验持续了三个星期。

结果

本工作的结果表明，NETA 的使用对子宫内膜上皮（增殖、自噬和凋亡）、腺体（坏死、凋亡或假分泌腺）以及基质和子宫肌层反应（粒细胞、结缔组织重塑、凋亡、肌细胞肥大）产生负面影响。

结论

本研究表明，NETA 对白化大鼠的子宫组织具有去同步的孕激素作用，从而阻止着床和妊娠。

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