Koutsouris D, Delatour-Hanss E, Hanss M
Biorheology. 1985;22(2):119-32. doi: 10.3233/bir-1985-22203.
The aim of this study is to assess the role of different physico-chemical factors on the deformability measurements by using the initial filtration flow rate method, and to differentiate between the membrane or internal origin of some rigidity changes. The deformability is maximum for the physiological pH value and it decreases sharply for hypotonic and hypertonic buffer. For normal RBC, the deformability is independent of the pO2 level and a small decrease is observed for increasing pCO2 values (with constant pH). A theoretical model of filtration for the "Hemorheometre" will be also developed.
本研究的目的是通过使用初始过滤流速法评估不同物理化学因素对变形性测量的作用，并区分某些刚性变化的膜源性或内部源性。生理pH值下变形性最大，在低渗和高渗缓冲液中则急剧下降。对于正常红细胞，变形性与pO2水平无关，而随着pCO2值增加（pH恒定）会观察到略有下降。还将建立“血液流变仪”过滤的理论模型。
