Khodabandehlou T, Le Devehat C
Unité de Recherches d'Hémorhéologie Clinique, Centre Hospitalier, Nevers.
J Mal Vasc. 1996;21(3):175-80.
This work aims to study the erythrocyte deformability by the Cell Transit Analyser "CTA". In the first place the investigations consist of the evaluation of the sensitivity of the CTA compared to that of the initial filtration flow rate method via Hanss Hemorheometer. The sensitivity is tested by using the blood samples whose deformability is artificially modified. In all experiments involving artificially-altered erythrocytes, the mean transit time is demonstrated to be a sensitive parameter to the changes in erythrocyte deformability. In the second place, the CTA is used to evaluate the RBC deformability in diabetic patients. The mean transit time of the RBC population from diabetic patients is found to be significantly higher than that of the healthy control subjects. This means a reduced deformability in diabetics. The analysis of the transit time distribution demonstrates that only a subpopulation is responsible for this disturbance.
这项工作旨在通过细胞传输分析仪“CTA”研究红细胞变形性。首先，研究包括评估CTA与通过汉斯血液流变仪的初始过滤流速法相比的灵敏度。通过使用变形性被人工改变的血样来测试灵敏度。在所有涉及人工改变红细胞的实验中，平均传输时间被证明是红细胞变形性变化的一个敏感参数。其次，CTA用于评估糖尿病患者的红细胞变形性。发现糖尿病患者红细胞群体的平均传输时间显著高于健康对照受试者。这意味着糖尿病患者的变形性降低。传输时间分布分析表明，只有一个亚群对此干扰负责。
