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开放标签安慰剂对过敏性鼻炎症状的影响:一项随机对照试验的系统评价和荟萃分析

The effect of open-label placebo on allergic rhinitis symptoms: A systematic review and meta-analysis of randomized controlled trials.

作者信息

Albazee Ebraheem, Alharran Abdullah M, Alzayed Mooza M

机构信息

Kuwait Institute for Medical Specializations (KIMS), Safat, Kuwait.

College of Medicine, Arabian Gulf University, Manama, Bahrain.

出版信息

Int Forum Allergy Rhinol. 2025 Jan;15(1):81-85. doi: 10.1002/alr.23444. Epub 2024 Aug 30.

DOI:10.1002/alr.23444
PMID:39212086
Abstract

The evidence regarding the open-label placebo effect on allergic rhinitis symptoms remains uncertain. Open-label placebo significantly reduced the frequency of symptoms in allergic rhinitis patients with similar safety profiles; however, there was no effect on the severity of symptoms and impairment due to symptoms. The statistically significant impact on symptom frequency can be considered not clinically significant.

摘要

关于开放标签安慰剂对过敏性鼻炎症状影响的证据仍不明确。开放标签安慰剂显著降低了具有相似安全性的过敏性鼻炎患者的症状频率;然而,对症状严重程度及症状所致功能损害并无影响。对症状频率的统计学显著影响可认为无临床意义。

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