Wang Kenny Y, Xu Timothy T, Dumbrava Mihai G, Oyemade Kafayat A, Lopez Dominguez Johanny, Hodge David O, White Launia J, Tooley Andrea A, Dalvin Lauren A
Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Ophthalmic Epidemiol. 2025 Jun;32(3):326-333. doi: 10.1080/09286586.2024.2379971. Epub 2024 Aug 30.
To determine the incidence and clinical characteristics of ocular adnexaltumors in Olmsted County, Minnesota.
Retrospective population-based cohort study of all patients residing in Olmsted County, Minnesota diagnosed with any ocular tumor from January 1, 2006, to December 31, 2015. The medical records of all patients with an incident diagnosis of any ocular adnexal tumor were reviewed using the Rochester Epidemiology Project medical record linkage system for patient demographics, tumor type, and histopathologic confirmation. Incidence rates were calculated per 100,000 person-years. Poisson regression analysis was used to analyze changes in incidence over time.
There were 717 patients diagnosed with ocular adnexal tumors during the 10-year study period, yielding an age- and sex-adjusted incidence rate of 59.7 per 100,000 (95% CI 55.4 to 64.0, < 0.05) per year. In total, 764 tumors were diagnosed. Most tumors were eyelid lesions ( = 756, 99.0%), which were mostly benign ( = 512, 67.8%) with epidermal inclusion cysts ( = 275, 36.0%), hidrocystoma ( = 70, 9.2%), and eyelid sebaceous cysts ( = 46, 6.1%) accounting for the majority. Malignant eyelid lesions ( = 244, 31.9%) were relatively common with basal cell carcinoma ( = 184, 24.1%) and squamous cell carcinoma ( = 49, 6.4%) having the highest frequencies. Orbital tumors ( = 8, 1.0%) were infrequent. Of the orbital tumors, the most common was lacrimal gland adenoidcystic carcinoma ( = 2, 25.0%).
In a population-based setting, most ocular adnexal tumors were benign eyelid lesions. Understanding the epidemiology of ocular adnexal tumors is important to aid providers in diagnosing and facilitating appropriate referrals of potentially vision- and life-threatening malignancies.
确定明尼苏达州奥姆斯特德县眼附属器肿瘤的发病率及临床特征。
对2006年1月1日至2015年12月31日期间居住在明尼苏达州奥姆斯特德县、被诊断患有任何眼肿瘤的所有患者进行基于人群的回顾性队列研究。使用罗切斯特流行病学项目医疗记录链接系统，对所有初次诊断为眼附属器肿瘤患者的医疗记录进行审查，以获取患者人口统计学信息、肿瘤类型和组织病理学确诊情况。计算每10万人年的发病率。采用泊松回归分析来分析发病率随时间的变化。
在为期10年的研究期间，有717例患者被诊断患有眼附属器肿瘤，年龄和性别调整后的发病率为每年每10万人59.7例（95%可信区间55.4至64.0，P<0.05）。共诊断出764个肿瘤。大多数肿瘤为眼睑病变（n=756，99.0%），其中大多为良性（n=512，67.8%），表皮样囊肿（n=275，36.0%）、汗腺囊瘤（n=70，9.2%）和眼睑皮脂腺囊肿（n=46，6.1%）占多数。恶性眼睑病变（n=244，31.9%）相对常见，其中基底细胞癌（n=184，24.1%）和鳞状细胞癌（n=49，6.4%）最为常见。眼眶肿瘤（n=8，1.0%）较少见。在眼眶肿瘤中，最常见的是泪腺腺样囊性癌（n=2，25.0%）。
在基于人群的研究中，大多数眼附属器肿瘤为良性眼睑病变。了解眼附属器肿瘤的流行病学对于帮助医生诊断以及促进对可能危及视力和生命的恶性肿瘤进行适当转诊非常重要。
