Amstutz H, Munz P, Heyer W D, Leupoid U, Kohli J
Cell. 1985 Apr;40(4):879-86. doi: 10.1016/0092-8674(85)90347-2.
In many cases the multiple genes coding for one specific tRNA are dispersed throughout the genome. The members of such a gene family nevertheless maintain a common nucleotide sequence during evolution. A major mechanism contributing to this concerted evolution is intergenic conversion. Here we show that it occurs between three tRNA genes of related sequence residing on different chromosomes of Schizosaccharomyces pombe. Sequence analysis of converted genes indicates that blocks of a minimal length of 18-33 bp and of a maximal length of 190 bp can be transferred from one gene to the other. During meiosis the frequency of these transfers lies in the order of 10(-5) per progeny spore. Information transfer between any two members of the gene family occurs in both directions.
在许多情况下，编码一种特定tRNA的多个基因分散在整个基因组中。然而，这样一个基因家族的成员在进化过程中保持着共同的核苷酸序列。促成这种协同进化的一个主要机制是基因间转换。在这里我们表明，它发生在粟酒裂殖酵母不同染色体上的三个相关序列的tRNA基因之间。对转换基因的序列分析表明，长度最小为18 - 33 bp、最大为190 bp的片段可以从一个基因转移到另一个基因。在减数分裂期间，这些转移的频率约为每个后代孢子10^(-5)。基因家族中任意两个成员之间的信息转移是双向发生的。
