Department of Ophthalmology, Pusan National University College of Medicine, Busan, Korea.
Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
PLoS One. 2024 Aug 30;19(8):e0306656. doi: 10.1371/journal.pone.0306656. eCollection 2024.
The invention of Light Emitting Diode (LED) revolutionized energy-efficient illumination, but concerns persist regarding the potential harm of blue light to our eyes. In this study, we scrutinized the impact of LED light characteristics on eyes using two cell types: M-1 (rich in mitochondria) and CD-1 (neuronal). Variations in color rendering index (CRI) and correlated color temperature (CCT) were investigated, alongside exposure durations ranging from 0 to 24 hours. The findings illuminated the potential benefits of high-quality LED lighting, characterized by a high CRI and low CCT, which emits a greater proportion of red light. This form of lighting was associated with enhanced cell proliferation, elevated ATP levels, and reduced oxidative stress. In contrast, LEDs with low CRI and high CCT exhibited adverse effects, diminishing cell viability and increasing oxidative stress. These results suggest that high-quality LED lighting may have neuroprotective potential as a treatment option, such as for retinal ganglion cells.
发光二极管（LED）的发明彻底改变了节能照明，但人们仍然担心蓝光对眼睛可能造成的伤害。在这项研究中，我们使用两种细胞类型：M-1（富含线粒体）和 CD-1（神经元）来仔细研究 LED 光特性对眼睛的影响。研究了显色指数（CRI）和相关色温（CCT）的变化，以及从 0 到 24 小时的不同暴露时间。研究结果揭示了高质量 LED 照明的潜在益处，其特点是高 CRI 和低 CCT，发出更多的红光。这种形式的照明与增强的细胞增殖、升高的 ATP 水平和降低的氧化应激有关。相比之下，CRI 低和 CCT 高的 LED 则表现出不利影响，降低了细胞活力并增加了氧化应激。这些结果表明，高质量的 LED 照明可能具有神经保护潜力，可作为治疗选择，例如治疗视网膜神经节细胞。
