Department of Rehabilitation and Sports Medicine, University Hospital Ostrava, Czechia; Faculty of Medicine, University of Ostrava, Czechia; Department of Clinical Neurosciences, University of Ostrava, Czechia.
Exercise Biology, Dep. Public Health, Aarhus University, Denmark; The Danish MS Hospitals, Ry and Haslev, Denmark.
Mult Scler Relat Disord. 2024 Oct;90:105827. doi: 10.1016/j.msard.2024.105827. Epub 2024 Aug 17.
For persons with multiple sclerosis (pwMS), exercise is known to be safe and effective at treating several symptoms and it may even be disease-modifying. However, exercise can trigger heat intolerance, exercise-induced heat sensitivity (EIHS), which may cause some pwMS to refrain from exercise. No review has yet summarized the existing knowledge on EIHS in pwMS. Therefore, the purpose of the present review was to clarify the terminology, summarize both the prevalence of EIHS and the current knowledge of underlying mechanisms, and provide an overview of existing treatment options and clinical management of EIHS in pwMS.
A scoping review was performed.
As no clear definition could be identified in the literature, we propose a definition of EIHS. Aspects related to EIHS are reported in 29-80 % of all pwMS. The mechanisms underlying EIHS are not well understood but seem to include axon demyelination, CNS lesions, abnormal sudomotor function and sweating, abnormal afferent thermosensory function, disease stability, and abnormal neuropsychological responses. The severity of EIHS depends on the applied exercise modality, intensity, and format, and can be further reduced when applying different cooling interventions or garments before and/or during exercise.
EIHS appears frequently in pwMS, but the underlying mechanisms are still only sparsely understood. EIHS severity depends on exercise-related factors and can be reduced by cooling interventions.
对于多发性硬化症患者（pwMS）来说，运动已被证明是安全且有效的，可以治疗多种症状，甚至可能具有疾病修饰作用。然而，运动可能会引发热不耐受，即运动引起的热敏感（EIHS），这可能导致一些 pwMS 避免运动。目前尚无文献综述总结 EIHS 在 pwMS 中的现有知识。因此，本综述的目的是阐明 EIHS 的术语，总结 EIHS 的患病率和当前对潜在机制的认识，并概述 pwMS 中 EIHS 的现有治疗选择和临床管理。
进行了范围综述。
由于在文献中无法确定明确的定义，我们提出了 EIHS 的定义。在所有 pwMS 中，有 29-80%报告了与 EIHS 相关的方面。EIHS 的潜在机制尚不清楚，但似乎包括轴突脱髓鞘、中枢神经系统病变、异常自主神经功能和出汗、异常传入热敏感觉功能、疾病稳定性和异常神经心理反应。EIHS 的严重程度取决于所应用的运动方式、强度和形式，并且在运动前和/或运动期间应用不同的冷却干预措施或服装时可以进一步降低。
EIHS 在 pwMS 中很常见，但潜在机制仍知之甚少。EIHS 的严重程度取决于与运动相关的因素，可以通过冷却干预来降低。
