Grosu Cristina, Ignat Emilian Bogdan, Alexa Daniel, Ciubotaru Alin, Leon Maria Magdalena, Maștaleru Alexandra, Popescu Gabriela, Cumpăt Carmen Marinela, Cucu Laura-Elena, Smihor Mădălina Irina, Trofin Dan
Department of Neurology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Clinical Rehabilitation Hospital, 700661 Iasi, Romania.
Nutrients. 2025 Aug 21;17(16):2713. doi: 10.3390/nu17162713.
Multiple sclerosis (MS) is a chronic, immune-mediated neurological disorder with increasing global prevalence. Emerging evidence underscores the role of lifestyle interventions (particularly diet and physical activity) in modulating disease progression and improving quality of life. This narrative review synthesizes current scientific literature on the effects of dietary interventions, including the Mediterranean, ketogenic, Swank, Wahls, gluten-free, and fasting-based diets, alongside various physical activity regimens. The Mediterranean and ketogenic diets show promise in reducing inflammation, enhancing neuroprotection, and improving metabolic health. Similarly, structured physical activity (including aerobic, resistance, sensorimotor, and mind-body exercises) demonstrates benefits in mobility, fatigue, and mental well-being. The review highlights the need for personalized, sustainable approaches that integrate nutritional and exercise-based strategies for optimal MS management in the long term.
多发性硬化症（MS）是一种慢性、免疫介导的神经系统疾病，在全球的患病率呈上升趋势。新出现的证据强调了生活方式干预（特别是饮食和体育活动）在调节疾病进展和改善生活质量方面的作用。这篇叙述性综述综合了当前关于饮食干预效果的科学文献，包括地中海饮食、生酮饮食、斯旺克饮食、瓦尔兹饮食、无麸质饮食和禁食饮食，以及各种体育活动方案。地中海饮食和生酮饮食在减轻炎症、增强神经保护和改善代谢健康方面显示出前景。同样，有组织的体育活动（包括有氧运动、阻力运动、感觉运动和身心锻炼）在改善活动能力、减轻疲劳和促进心理健康方面也有好处。该综述强调了需要采用个性化、可持续的方法，将基于营养和运动的策略结合起来，以便长期对多发性硬化症进行最佳管理。
