Resident of Large Animal Internal Medicine, Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Iran.
Abadan University of Medical Sciences, Abadan, Iran.
Clin Chim Acta. 2025 Jan 1;564:119946. doi: 10.1016/j.cca.2024.119946. Epub 2024 Aug 28.
Ovarian cancer, a prevalent and deadly cancer among women, presents a significant challenge for early detection due to its heterogeneous nature. MicroRNAs, short non-coding regulatory RNA fragments, play a role in various cellular processes. Aberrant expression of these microRNAs has been observed in the carcinogenesis-related processes of many cancer types. Numerous studies highlight the critical role of microRNAs in the initiation and progression of ovarian cancer. Given their clinical importance and predictive value, there has been considerable interest in developing simple, prompt, and sensitive miRNA biosensor strategies. Among these, electrochemical sensors have demonstrated advantageous characteristics such as simplicity, sensitivity, low cost, and scalability. These microRNA-based electrochemical biosensors are valuable tools for early detection and point-of-care applications. This article discusses the potential role of microRNAs in ovarian cancer and recent advances in the development of electrochemical biosensors for miRNA detection in ovarian cancer samples.
卵巢癌是女性中常见且致命的癌症，由于其异质性，早期检测具有很大的挑战性。microRNAs 是一类短的非编码调控 RNA 片段，在各种细胞过程中发挥作用。这些 microRNAs 的异常表达在许多癌症类型的癌变相关过程中都有观察到。大量研究强调了 microRNAs 在卵巢癌发生和发展中的关键作用。鉴于其临床重要性和预测价值，人们对开发简单、快速、灵敏的 miRNA 生物传感器策略产生了浓厚的兴趣。在这些方法中，电化学传感器具有简单、灵敏、低成本和可扩展性等优势。基于 microRNA 的电化学生物传感器是早期检测和即时护理应用的有价值工具。本文讨论了 microRNAs 在卵巢癌中的潜在作用，以及用于卵巢癌样本中 miRNA 检测的电化学生物传感器的最新进展。
