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重组人白细胞介素2作为一种促进B细胞生长和分化的因子。

Recombinant human interleukin 2 acts as a B cell growth and differentiation promoting factor.

作者信息

Emmrich F, Moll H, Simon M M

出版信息

Immunobiology. 1985 Feb;169(1):97-102. doi: 10.1016/S0171-2985(85)80057-7.

DOI:10.1016/S0171-2985(85)80057-7
PMID:3921456
Abstract

Human B cells appropriately activated by a B cell mitogen are rendered susceptible to human Interleukin 2 (IL-2) as demonstrated with recombinant human IL-2 (rec. h IL-2). They show increased proliferation and drastically enhanced immunoglobulin secretion. Susceptibility to IL-2 is accompanied with the expression of the IL-2 receptor (Tac antigen) on B cells. The data suggest that IL-2 is one of the lymphokines directly involved in the activation of B lymphocytes.

摘要

如用重组人白细胞介素2（rec. h IL-2）所证实的，被B细胞促有丝分裂原适当激活的人B细胞对人白细胞介素2（IL-2）变得敏感。它们表现出增殖增加和免疫球蛋白分泌大幅增强。对IL-2的敏感性伴随着B细胞上IL-2受体（Tac抗原）的表达。这些数据表明，IL-2是直接参与B淋巴细胞激活的淋巴因子之一。

相似文献

1
Recombinant human interleukin 2 acts as a B cell growth and differentiation promoting factor.重组人白细胞介素2作为一种促进B细胞生长和分化的因子。
Immunobiology. 1985 Feb;169(1):97-102. doi: 10.1016/S0171-2985(85)80057-7.
2
Synergy of B cell growth factor and interleukin 2 in the proliferation of activated human B cells.B细胞生长因子与白细胞介素2在活化的人B细胞增殖中的协同作用。
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In vitro maturation of B cells in chronic lymphocytic leukemia. I. Synergistic action of phorbol ester and interleukin 2 in the induction of Tac antigen expression and interleukin 2 responsiveness in leukemic B cells.慢性淋巴细胞白血病中B细胞的体外成熟。I. 佛波酯和白细胞介素2在白血病B细胞中诱导Tac抗原表达及白细胞介素2反应性方面的协同作用。
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B cell growth and differentiation factors interact with receptors distinct from the interleukin 2 receptor.B细胞生长和分化因子与不同于白细胞介素2受体的受体相互作用。
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Recombinant IL 2 but not recombinant interferon-gamma stimulates both proliferation and IgM secretion in a Ly-1+ clone of neoplastic murine B cells (BCL1).重组白细胞介素2而非重组γ干扰素能刺激肿瘤性小鼠B细胞（BCL1）的Ly-1 +克隆中的细胞增殖和IgM分泌。
J Immunol. 1986 Nov 15;137(10):3205-10.
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Interleukin 2 acts directly on a Tac-positive cloned B cell line established from a patient with adult T cell leukemia.
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Demonstration that human B cells respond differently to interleukin 2 and B cell differentiation factor based on their stages of maturation.基于人类B细胞的成熟阶段，证明其对白细胞介素2和B细胞分化因子的反应不同。
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In vivo and in vitro expression of an interleukin 2 receptor by murine B and T lymphocytes.白细胞介素2受体在小鼠B淋巴细胞和T淋巴细胞中的体内及体外表达
J Immunol. 1986 Oct 1;137(7):2252-9.
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Analysis of the mechanisms of T cell-dependent polyclonal activation of human B cells. Induction of human B cell responses by fixed activated T cells.人B细胞T细胞依赖性多克隆激活机制的分析。固定活化T细胞对人B细胞反应的诱导。
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Human recombinant IL-3 is a growth factor for normal B cells.人重组白细胞介素-3是正常B细胞的生长因子。
J Immunol. 1992 Jan 15;148(2):491-7.

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