Maruyama Y, Beach J L, Hazle J, Ashtari M, Schroy C B, Olson M H
Int J Radiat Oncol Biol Phys. 1985 May;11(5):927-35. doi: 10.1016/0360-3016(85)90115-4.
252Cf (Cf) was used to treat tumors of the cervix and uterus with neutron brachytherapy (NT) in an ongoing clinical trial. Tandem and ovoids insertions were used and combinations of single and multiple applications along with high dose whole pelvic irradiation. Dosimetric analysis of treated cases for patterns of tissue dose were carried out. Tissue dose for Cf-NT was, in general, high for neutron components in the central pelvis only, and fell off rapidly with distance from the applicators. The majority and balance of therapeutic dose was contributed by low linear energy transfer (LET) high energy photon beam radiation to the whole pelvis. Comparison with fast neutron beam therapy (NBT) isodose curves showed that much more homogeneous neutron dose was delivered to the pelvic tumor and organs by NBT. Complication frequency has been reported to be higher for neutron beam therapy than for Cf-NT. It appears that the higher integral neutron biological dose to normal tissues for NBT compared to intracavitary Cf-NT probably contributed to the frequency of side effects.
在一项正在进行的临床试验中，使用252锎（Cf）通过中子近距离治疗（NT）来治疗子宫颈和子宫肿瘤。采用了串联和卵圆形施源器插入，并结合了单次和多次应用以及高剂量全盆腔照射。对治疗病例进行了组织剂量模式的剂量学分析。Cf - NT的组织剂量一般仅在中盆腔的中子成分中较高，并且随着与施源器距离的增加而迅速下降。治疗剂量的大部分和其余部分是由低线性能量传递（LET）的高能光子束对全盆腔的辐射贡献的。与快中子束治疗（NBT）等剂量曲线的比较表明，NBT向盆腔肿瘤和器官传递的中子剂量更加均匀。据报道，中子束治疗的并发症发生率高于Cf - NT。与腔内Cf - NT相比，NBT对正常组织的积分中子生物剂量更高，这可能是导致副作用发生率较高的原因。
