Maruyama Y, Beach J L, Feola J
Radiology. 1980 Dec;137(3):775-81. doi: 10.1148/radiology.137.3.6777827.
Fast-neutron-beam therapy and low-dose-rate fast-neutron intracavitary therapy of cervical carcinoma are effective in producing regression of advanced tumors. However, effectiveness is critically dependent on the schedule by which they are used in combination with fractionated external low-linear-energy-transfer (LET) therapy. Neutron-beam therapy is now alternated frequently with fractionated external radiotherapy (mixed beam). Intracavitary neutron therapy, scheduled before fractionated external-beam photon therapy, was maximally effective. These findings indicate that traditional concepts developed for the use of conventional low-LET therapy may need to be altered to use neutrons for therapy and to achieve improved local control of advanced cancers.
快中子束治疗和低剂量率快中子腔内治疗宫颈癌对晚期肿瘤的消退有效。然而，其有效性关键取决于与分次外照射低线性能量传递（LET）治疗联合使用的方案。现在中子束治疗经常与分次外照射放疗（混合束）交替进行。腔内中子治疗安排在分次外照射光子治疗之前，效果最佳。这些发现表明，为使用传统低LET治疗而形成的传统观念可能需要改变，以便将中子用于治疗并改善晚期癌症的局部控制。
