Department of Cardiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, 7 Weiwu Street, Zhengzhou 45000, Zhengzhou, China.
Department of Pathophysiology, School of Basic Medicine, Sanquan College of Xinxiang Medical University, Xinxiang, China.
BMC Cardiovasc Disord. 2024 Aug 30;24(1):465. doi: 10.1186/s12872-024-04115-3.
The American Heart Association (AHA) recently defined a new concept of cardiovascular health-Life's Essential 8 (LE8). We sought to examine whether LE8 score is associated with a risk of all-cause and cardiovascular disease (CVD)-related mortality in individuals with hypertension.
This longitudinal study analyzed data from the National Health and Nutrition Examination Survey from 2007 to 2018 in people 20 years or older with hypertension. LE8 score (range 0-100) was measured according to the AHA definition and divided into unweighted tertiles into groups T1 (< 50.00), T2 (50.00-61.25), and T3 (≥ 61.25). Primary outcomes included all-cause mortality and CVD-specific mortality.
A total of 15,318 individuals with hypertension were included in this study, with a mean ± standard error age of 55.06 ± 0.25 years. During the median follow-up period of 76 months, 2525 all-cause mortality occurred, of which 806 were due to CVD. Compared with participants with hypertension in the T1 group, those in T2 and T3 respectively had 28% (adjusted HR = 0.72, 95% CI 0.63-0.83, P < 0.001) and 39% (adjusted HR = 0.61, 95% CI 0.52-0.72, P < 0.001) lower risk of all-cause mortality, the T2 and T3 groups were associated with 32% (adjusted HR = 0.68, 95% CI 0.53-0.88, P = 0.003) and 36% (adjusted HR = 0.64, 95% CI 0.49-0.84, P = 0.001) reduced risk of CVD mortality separately.
A higher LE8 score is associated with a lower risk of all-cause mortality and CVD mortality, and the higher LE8 score can be maintained in the clinic to improve prognosis by modifying the diet and lifestyle habits of individuals with hypertension.
美国心脏协会（AHA）最近定义了一个新的心血管健康概念——生命必需的 8 项（LE8）。我们试图研究 LE8 评分是否与高血压患者全因和心血管疾病（CVD）相关死亡率相关。
这项纵向研究分析了 2007 年至 2018 年全国健康和营养检查调查中 20 岁及以上高血压患者的数据。根据 AHA 的定义，LE8 评分（范围 0-100）进行测量，并分为未加权三分位数组 T1（<50.00）、T2（50.00-61.25）和 T3（≥61.25）。主要结局包括全因死亡率和 CVD 特异性死亡率。
这项研究共纳入 15318 名高血压患者，平均年龄为 55.06±0.25 岁。在中位随访 76 个月期间，发生 2525 例全因死亡，其中 806 例死于 CVD。与 T1 组的高血压患者相比，T2 和 T3 组的全因死亡率分别降低了 28%（调整后的 HR=0.72，95%CI 0.63-0.83，P<0.001）和 39%（调整后的 HR=0.61，95%CI 0.52-0.72，P<0.001），T2 和 T3 组分别降低了 32%（调整后的 HR=0.68，95%CI 0.53-0.88，P=0.003）和 36%（调整后的 HR=0.64，95%CI 0.49-0.84，P=0.001）的 CVD 死亡率风险。
较高的 LE8 评分与全因死亡率和 CVD 死亡率降低相关，通过改变高血压患者的饮食和生活习惯，可以在临床中维持较高的 LE8 评分，从而改善预后。
