School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China.
School of Biomedical Engineering, Shanghai Jiao Tong University, Minhang District, 800 Dongchuan Road, Shanghai, 200240, China.
Biomed Microdevices. 2024 Aug 31;26(3):38. doi: 10.1007/s10544-024-00722-1.
Fecal incontinence (FI) referred to the inability to control the leakage of solid, liquid, or gaseous feces, the artificial anal sphincter (AAS) was the last resort for patients with FI except enterostomy. In order to the clinical application value of AAS was improved, the detection and analysis of intestinal pressure information was very necessary. Biaxial actuated artificial anal sphincter (BAAS) was a new type of AAS, which not only had a stable, long-term and safe energy supply, but also could provide real-time feedback of intestinal pressure information. In this paper, the BAAS was implanted into piglets for a long-term animal experiment. Piglets' life habits, defecation habits and intestinal pressure were analyzed. The analysis results showed that the BAAS system had good feces control effect, when the actuator of the BAAS system was closed, there was basically no fecal leakage of piglets, and when the actuator of the BAAS system was opened, the piglets could defecate normally. Under the normal condition of the piglets' health state and the BAAS's operating state, the accuracy of the defecation perception reached to 65.79%. This study realized the in-depth study of the mechanism of piglets' defecation, and provided guidance for the development of a new generation of AAS.
粪便失禁（FI）是指无法控制固体、液体或气体粪便的泄漏，人工肛门括约肌（AAS）是 FI 患者除肠造口术外的最后手段。为了提高 AAS 的临床应用价值，非常有必要检测和分析肠道压力信息。双轴驱动人工肛门括约肌（BAAS）是一种新型的 AAS，它不仅具有稳定、长期和安全的能量供应，还可以提供实时的肠道压力信息反馈。本文将 BAAS 植入仔猪进行长期动物实验，分析仔猪的生活习惯、排便习惯和肠道压力。分析结果表明，BAAS 系统具有良好的粪便控制效果，当 BAAS 系统的执行器关闭时，仔猪基本上没有粪便泄漏，当 BAAS 系统的执行器打开时，仔猪可以正常排便。在仔猪健康状态和 BAAS 运行状态正常的情况下，排便感知的准确性达到 65.79%。本研究深入研究了仔猪排便的机制，为新一代 AAS 的开发提供了指导。
