Marchiondo A A, Andersen F L
J Helminthol. 1985 Mar;59(1):29-38. doi: 10.1017/s0022149x00034441.
The in vivo efficacy and ultrastructural effects of mitomycin C were determined against alveolar hydatid disease in experimentally infected animals and compared to mebendazole treatment. Mitomycin C inhibited the mean cyst mass of treated versus control animals by 84.1% which was statistically significant at the alpha = 0.01 level. Mebendazole given daily inhibited the mean cyst mass by 80.1%, while mebendazole administration on the same treatment schedule as that used for mitomycin C inhibited the mean cyst mass by 70.4%. Ultrastructurally, mitomycin C was not observed to affect the tegumental microtriches (microvilli) or the microtubular system. However, an increase in the number and accumulation of round to oval electrondense vesicles was observed within the subtegument. These inclusion bodies became vacuolated, subsequently degenerated, and formed myelin-like figures. Mitomycin C, like mebendazole, was only cystistatic in its effects on the cyst stage of Echinococcus multilocularis as evidenced by the growth of treated cyst material following inoculation into helminth-free animals.
在实验感染的动物中，测定了丝裂霉素C对肺泡型包虫病的体内疗效和超微结构影响，并与甲苯咪唑治疗进行了比较。与对照动物相比，丝裂霉素C使治疗动物的平均囊肿质量抑制了84.1%，在α = 0.01水平具有统计学意义。每日给予甲苯咪唑使平均囊肿质量抑制了80.1%，而按照与丝裂霉素C相同的治疗方案给予甲苯咪唑，使平均囊肿质量抑制了70.4%。在超微结构上，未观察到丝裂霉素C影响皮层微毛（微绒毛）或微管系统。然而，在皮层下观察到圆形至椭圆形电子致密囊泡的数量增加和积聚。这些包涵体空泡化，随后退化，并形成髓鞘样结构。与甲苯咪唑一样，丝裂霉素C对多房棘球绦虫囊肿阶段的作用只是抑制囊肿生长，这一点在将治疗后的囊肿材料接种到无蠕虫动物体内后囊肿仍生长得到了证明。
