Başkent University Faculty of Medicine, Adana Dr Turgut Noyan Application and Research Hospital, Department of Gynecology and Obstetrics, Adana, Turkey.
Başkent University Faculty of Medicine, Adana Dr Turgut Noyan Application and Research Hospital, Department of Gynecology and Obstetrics, Adana, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2024 Nov;302:38-42. doi: 10.1016/j.ejogrb.2024.08.040. Epub 2024 Aug 27.
Unicornuate uterus, which is a rare congenital anomaly, has been associated with obstetric and perinatal complications. The aim of this study is to evaluate the reproductive outcomes of patients with unicornuate uterus, and also to compare them with outcomes of infertile patients without a Müllerian anomaly.
Retrospective analyses of the data of 18-40 year old infertile patients with unicornuate uterus diagnosed in between January 2012 and December 2022, and a control group with the same number of patients, with age and infertility durations matched were performed. Demographic data, cycle parameters and reproductive outcomes of the unicornuate uterus and control groups were compared.
A total of 75 patients with unicornuate uterus and a control group of 75 infertile patients without a Müllerian anomaly were included in the study. Totally, 116 and 91 pregnancies were achieved at unicornuate uterus and the control groups, respectively. Ectopic pregnancy rates (10.3 % vs 2.2 %, OR = 5.53, 95 %CI [1.17-26.21]) and malpresentation rates (29 % vs 0 %, OR = 1.40, 95 %CI [1.12-1.76]) were significantly higher and newborn birth weights in singleton pregnancies were significantly lower in the unicornuate group (3000 g vs 3455 g, p = 0.005). No significant difference was found in other obstetric parameters.
Unicornuate uterus constitutes a small portion of all congenital uterine anomalies. Although increased ectopic pregnancy and malpresentation rates with diminished birth weights were found in the unicornuate group in our study, live birth rates and preterm deliveries did not differ significantly between the two groups. However, patients should be counseled on this issue both during the reproductive treatment process and during pregnancy, and should be followed closely.
单角子宫是一种罕见的先天性畸形，与产科和围产期并发症有关。本研究旨在评估单角子宫患者的生殖结局，并将其与无 Müllerian 异常的不孕患者的结局进行比较。
对 2012 年 1 月至 2022 年 12 月期间诊断为单角子宫的 18-40 岁不孕患者的资料进行回顾性分析，并与年龄和不孕时间匹配的单角子宫和对照组各 75 例患者进行比较。比较单角子宫和对照组的人口统计学数据、周期参数和生殖结局。
本研究共纳入 75 例单角子宫患者和 75 例无 Müllerian 异常的不孕对照组患者。单角子宫组和对照组分别获得 116 次和 91 次妊娠。异位妊娠率（10.3%比 2.2%，OR=5.53，95%CI[1.17-26.21]）和胎位不正率（29%比 0%，OR=1.40，95%CI[1.12-1.76]）显著升高，单胎新生儿出生体重显著降低（3000g 比 3455g，p=0.005）。两组其他产科参数无显著差异。
单角子宫构成所有先天性子宫畸形的一小部分。尽管在我们的研究中单角子宫组的异位妊娠和胎位不正率增加，新生儿出生体重降低，但两组的活产率和早产率无显著差异。然而，在生殖治疗过程中和怀孕期间，都应该对患者进行这方面的咨询，并密切随访。
