果蝇翅盘片段中的模式调控，这些片段表现出不同的伤口愈合情况。

Pattern regulation in fragments of Drosophila wing discs which show variable wound healing.

作者信息

Dale L, Bownes M

出版信息

J Embryol Exp Morphol. 1985 Feb;85:95-109.

Abstract

When complementary fragments of the imaginal wing disc of Drosophila are cultured for several days prior to inducing metamorphosis, usually one fragment will regenerate while the second duplicates. It has been proposed that wound healing plays an important part in disc regulation by initiating cell proliferation and determining the mode of regulation (regeneration/duplication). To test the latter proposal 15 types of wing disc fragments were examined for variability both in the mode of wound healing and the mode of pattern regulation. Two modes of wound healing were observed, regular - the two wound edges heal with each other, and irregular - each wound edge heals with itself. When cultured separately fragments that healed regularly regenerated, while fragments that healed irregularly duplicated. This suggests that the mode of wound healing determines the mode of pattern regulation.

摘要

在诱导变态发育前，将果蝇成虫翅芽的互补片段培养几天，通常一个片段会再生，而另一个则会复制。有人提出，伤口愈合通过启动细胞增殖和决定调节模式（再生/复制）在翅芽调节中起重要作用。为了验证后一种说法，研究人员检查了15种翅芽片段在伤口愈合模式和模式调节模式方面的变异性。观察到两种伤口愈合模式，规则型——两个伤口边缘相互愈合，不规则型——每个伤口边缘自行愈合。单独培养时，规则愈合的片段会再生，而不规则愈合的片段会复制。这表明伤口愈合模式决定了模式调节模式。