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患坏死性小肠结肠炎的早产儿的人乳微生物群、低聚糖谱和婴儿肠道微生物组。

Human milk microbiota, oligosaccharide profiles, and infant gut microbiome in preterm infants diagnosed with necrotizing enterocolitis.

机构信息

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Microbiology Department, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK.

出版信息

Cell Rep Med. 2024 Sep 17;5(9):101708. doi: 10.1016/j.xcrm.2024.101708. Epub 2024 Aug 30.

DOI:10.1016/j.xcrm.2024.101708
PMID:39216480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11524953/
Abstract

Necrotizing enterocolitis (NEC) is a severe intestinal disease of very preterm infants with mother's own milk (MOM) providing protection, but the contribution of the MOM microbiota to NEC risk has not been explored. Here, we analyze MOM of 110 preterm infants (48 NEC, 62 control) in a cross-sectional study. Breast milk contains viable bacteria, but there is no significant difference in MOM microbiota between NEC and controls. Integrative analysis between MOM microbiota, human milk oligosaccharides (HMOs), and the infant gut microbiota shows positive correlations only between Acinetobacter in the infant gut and Acinetobacter and Staphylococcus in MOM. This study suggests that NEC protection from MOM is not modulated through the MOM microbiota. Thus, "'restoring" the MOM microbiota in donor human milk is unlikely to reduce NEC, and emphasis should instead focus on increasing fresh maternal human milk intake and researching different therapies for NEC prevention.

摘要

坏死性小肠结肠炎（NEC）是一种严重的早产儿肠道疾病，母亲的自身奶（MOM）提供保护，但 MOM 微生物群对 NEC 风险的贡献尚未得到探索。在这里，我们在一项横断面研究中分析了 110 名早产儿的 MOM（48 名 NEC，62 名对照）。母乳中含有活菌，但 NEC 和对照组之间的 MOM 微生物群没有显著差异。MOM 微生物群、人乳寡糖（HMO）和婴儿肠道微生物群之间的综合分析表明，只有婴儿肠道中的不动杆菌与 MOM 中的不动杆菌和葡萄球菌之间存在正相关。这项研究表明，MOM 对 NEC 的保护不是通过 MOM 微生物群来调节的。因此，“恢复”捐赠人乳中的 MOM 微生物群不太可能降低 NEC 的发病率，而应重点增加新鲜母乳的摄入量，并研究预防 NEC 的不同疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/1bc57d9a5359/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/507eaf5fbdce/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/71c01f573a04/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/4313a4816cc9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/1bc57d9a5359/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/507eaf5fbdce/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/71c01f573a04/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/4313a4816cc9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9251/11524953/1bc57d9a5359/gr3.jpg

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本文引用的文献

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