Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
School of Computer, Electronics and Information, Guangxi University, Nanning 530004, China.
J Affect Disord. 2024 Dec 15;367:632-639. doi: 10.1016/j.jad.2024.08.100. Epub 2024 Aug 30.
Depression is a significant global health concern, projected to become the leading disease burden. Vascular burden has been implicated in the pathogenesis of depression. Conversely, whether depression independently influences the process of vascular aging is unknown. This study aims to investigate the mutual relationship between vascular age and depression.
Utilizing data from the National Health and Nutrition Examination Survey (NHANES), the study included 27,764 participants after exclusions. Depression was assessed using the Patient Health Questionnaire (PHQ-9). Vascular aging was assessed by estimated pulse wave velocity (ePWV) and the heart age/vascular age (HVA) based on Framingham Risk Score (FRS). The study employed weighted logistic regression and Cox proportional hazards models to analyze the association between vascular age and depression as well as its mortality risk. Mendelian randomization was utilized to explore the causal associations.
Individuals with depression exhibited a higher risk of an advanced vascular age over their chronological age. Mendelian randomization analysis indicated a causal relationship between depression and arterial stiffness. A significant association was found between vascular age and depression incidence with odds ratios ranging from 1.10 to 1.38. As vascular age increased, the risk of mortality in individuals with depression increased by 22 % and 46 %, respectively.
The study design limits the exploration of the dynamic relationship between changes in vascular age and depression due to the single timepoint measurement.
This study highlights the bidirectional relationship between depression and vascular age. Vascular age is a significant biomarker for the risk and prognosis of depression, while depression may contribute to vascular aging, which underscores the importance of integrated strategies for managing both vascular health and depression.
抑郁症是一个重大的全球健康问题，预计将成为导致疾病负担的首要原因。血管负担与抑郁症的发病机制有关。相反，抑郁症是否独立影响血管老化过程尚不清楚。本研究旨在探讨血管年龄与抑郁症之间的相互关系。
利用国家健康和营养检查调查（NHANES）的数据，排除后纳入了 27764 名参与者。使用患者健康问卷（PHQ-9）评估抑郁。通过估计脉搏波速度（ePWV）和基于弗雷明汉风险评分（FRS）的心脏年龄/血管年龄（HVA）评估血管年龄。采用加权逻辑回归和 Cox 比例风险模型分析血管年龄与抑郁以及其死亡率风险之间的关系。采用孟德尔随机化探讨因果关系。
患有抑郁症的个体表现出高于其实际年龄的血管年龄提前。孟德尔随机化分析表明，抑郁症与动脉僵硬度之间存在因果关系。血管年龄与抑郁发生之间存在显著关联，比值比范围为 1.10 至 1.38。随着血管年龄的增加，患有抑郁症的个体的死亡率风险分别增加了 22%和 46%。
由于仅进行了单次测量，研究设计限制了对血管年龄和抑郁症之间动态关系的探索。
本研究强调了抑郁症和血管年龄之间的双向关系。血管年龄是评估抑郁风险和预后的重要生物标志物，而抑郁症可能导致血管老化，这突显了综合管理血管健康和抑郁症的重要性。
