Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box 19395-4763, Tehran, Islamic Republic of Iran.
School of Medicine, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
Cardiovasc Diabetol. 2024 Aug 31;23(1):321. doi: 10.1186/s12933-024-02387-9.
The association between baseline triglyceride glucose index (TyG index) and incident non-communicable diseases, mainly in Asian populations, has been reported. In the current study, we aimed to evaluate the association between index-year, average, and visit-to-visit variability (VVV) of the TyG index with incident type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease (CVD), and all-cause mortality among the Iranian population.
The study population included 5220 participants (2195 men) aged ≥ 30 years. TyG index was calculated as Ln (fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2). Average values of the TyG index and also VVV (assessed by the standard deviation (SD) and variability independent of mean) were derived during the exposure period from 2002 to 2011 (index-year). Multivariable Cox proportional hazards regression models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of the TyG index for incident different health outcomes.
During more than 6 years of follow-up after the index year, 290, 560, 361, and 280 events of T2DM, hypertension, CVD, and all-cause mortality occurred. 1-SD increase in the TyG index values at the index-year was independently associated with the incident T2DM [HR (95% CI) 2.50 (2.13-2.93)]; the corresponding values for the average of TyG index were 2.37 (2.03-2.76), 1.12 (0.99-1.26, p = 0.05), 1.18 (1.01-1.36), and 1.29 (1.08-1.53) for incident T2DM, hypertension, CVD, and all-cause mortality, respectively. Compared to the first tertile, tertile 3 of VVV of the TyG index was independently associated with incident hypertension [1.33 (1.07-1.64), P <0.01]. Likewise, a 1-SD increase in VVV of the TyG index was associated with an 11% excess risk of incident hypertension [1.11 (1.02-1.21)]. However, no association was found between the VVV of the TyG index and other outcomes. Moreover, the impact of index-year and average values of the TyG index was more prominent among women regarding incident CVD (P for interactions < 0.05).
Although the higher TyG index at index-year and its VVV were only associated with the incident T2DM and hypertension, respectively, its average value was capable of capturing the risk for all of the health outcomes.
已有研究报道，基线甘油三酯-葡萄糖指数（TyG 指数）与非传染性疾病的发生之间存在关联，这些研究主要集中在亚洲人群。本研究旨在评估 TyG 指数在伊朗人群中与 2 型糖尿病（T2DM）、高血压、心血管疾病（CVD）和全因死亡率的发生相关联。
研究人群包括 5220 名（2195 名男性）年龄≥30 岁的参与者。TyG 指数的计算方法为 Ln（空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2）。在 2002 年至 2011 年的暴露期间（指数年），通过标准差（SD）和均值独立变异（VVV）评估 TyG 指数的平均值和 VVV（评估方法为标准差）。使用多变量 Cox 比例风险回归模型来估计 TyG 指数与不同健康结局的发生的风险比（HR）和 95%置信区间（CI）。
在指数年后的 6 年多随访期间，发生了 290 例 T2DM、560 例高血压、361 例 CVD 和 280 例全因死亡事件。在指数年 TyG 指数每增加 1 个标准差，与 T2DM 的发生独立相关[HR（95%CI）为 2.50（2.13-2.93）]；TyG 指数平均值的对应值分别为 2.37（2.03-2.76）、1.12（0.99-1.26，p=0.05）、1.18（1.01-1.36）和 1.29（1.08-1.53），分别为 T2DM、高血压、CVD 和全因死亡事件。与第一三分位数相比，TyG 指数 VVV 的第三分位数与高血压的发生独立相关[1.33（1.07-1.64），P<0.01]。同样，TyG 指数 VVV 增加 1 个标准差与高血压发生的风险增加 11%相关[1.11（1.02-1.21）]。然而，TyG 指数 VVV 与其他结局之间没有关联。此外，TyG 指数的指数年和平均值与女性 CVD 的发生风险（P 值<0.05）之间存在显著相关性。
尽管 TyG 指数在指数年和 VVV 较高仅与 T2DM 和高血压的发生相关，但其平均值能够捕获所有健康结局的风险。
