Investigating changes of functional brain networks in major depressive disorder by graph theoretical analysis of resting-state fMRI.

BACKGROUND

Major Depressive Disorder (MDD), as a chronic mental disorder, causes changes in mood, thoughts, and behavior. The pathophysiology of the disorder and its treatment are still unknown. One of the most notable changes observed in patients with MDD through fMRI is abnormal functional brain connectivity.

METHODS

Preprocessed data from 60 MDD patients and 60 normal controls (NCs) were selected, which has been performed using the DPARSF toolbox. The whole-brain functional networks and topologies were extracted using graph theory-based methods. A two-sample, two-tailed t-test was used to compare the topological features of functional brain networks between the MDD and NCs groups using the DPABI-Net/Statistical Analysis toolbox.

RESULTS

The obtained results showed a decrease in both global and local efficiency in MDD patients compared to NCs, and specifically, MDD patients showed significantly higher path length values. Acceptable p-values were obtained with a small sample size and less computational volume compared to the other studies on large datasets. At the node level, MDD patients showed decreased and relatively decreased node degrees in the sensorimotor network (SMN) and the dorsal attention network (DAN), respectively, as well as decreased node efficiency in the SMN, default mode network (DMN), and DAN. Also, MDD patients showed slightly decreased node efficiency in the visual networks (VN) and the ventral attention network (VAN), which were reported after FDR correction with Q < 0.05.

LIMITATIONS

All participants were Chinese.

CONCLUSIONS

Collectively, increased path length, decreased global and local efficiency, and also decreased nodal degree and efficiency in the SMN, DAN, DAN, VN, and VAN were found in patients compared to NCs.