间充质干细胞的线粒体转移：机制与功能

Mitochondrial transfer from mesenchymal stem cells: Mechanisms and functions.

作者信息

Liu Qing, Zhang Xiaoxin, Zhu Tongxin, Xu Zhonghan, Dong Yingchun, Chen Bin

机构信息

Department of Periodontology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.

Central laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.

出版信息

Mitochondrion. 2024 Nov;79:101950. doi: 10.1016/j.mito.2024.101950. Epub 2024 Aug 31.

DOI:10.1016/j.mito.2024.101950

PMID:39218052

Abstract

Mesenchymal stem cells based therapy has been used in clinic for almost 20 years and has shown encouraging effects in treating a wide range of diseases. However, the underlying mechanism is far more complicated than it was previously assumed. Mitochondria transfer is one way that recently found to be employed by mesenchymal stem cells to exert its biological effects. As one way of exchanging mitochondrial components, mitochondria transfer determines both mesenchymal stem cells and recipient cell fates. In this review, we describe the factors that contribute to MSCs-MT. Then, the routes and mechanisms of MSCs-MT are summarized to provide a theoretical basis for MSCs therapy. Besides, the advantages and disadvantages of MSCs-MT in clinical application are analyzed.

摘要

基于间充质干细胞的疗法已在临床上应用了近20年，并在治疗多种疾病方面显示出令人鼓舞的效果。然而，其潜在机制比之前设想的要复杂得多。线粒体转移是最近发现的间充质干细胞发挥其生物学效应的一种方式。作为交换线粒体成分的一种方式，线粒体转移决定了间充质干细胞和受体细胞的命运。在这篇综述中，我们描述了促成间充质干细胞线粒体转移的因素。然后，总结了间充质干细胞线粒体转移的途径和机制，为间充质干细胞治疗提供理论依据。此外，还分析了间充质干细胞线粒体转移在临床应用中的优缺点。