Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Int J Biol Macromol. 2024 Nov;279(Pt 2):135210. doi: 10.1016/j.ijbiomac.2024.135210. Epub 2024 Aug 30.
Sirtuins, as NAD-dependent deacetylases, are widely found in eubacteria, archaea, and eukaryotes, and they play key roles in regulating cellular functions. Among these, SIRT7 stands out as a member discovered relatively late and studied less extensively. It is localized within the nucleus and displays enzymatic activity as an NAD-dependent deacetylase, targeting a diverse array of acyl groups. The role of SIRT7 in important cellular processes like gene transcription, cellular metabolism, cellular stress responses, and DNA damage repair has been documented in a number of studies conducted recently. These studies have also highlighted SIRT7's strong correlation with human diseases like aging, cancer, neurological disorders, and cardiovascular diseases. In addition, a variety of inhibitors against SIRT7 have been reported, indicating that targeting SIRT7 may be a promising strategy for inhibiting tumor growth. The purpose of this review is to thoroughly look into the structure and function of SIRT7 and to explore its potential value in clinical applications, offering an essential reference for research in related domains.
Sirtuins 作为 NAD 依赖性脱乙酰酶，广泛存在于真细菌、古菌和真核生物中，它们在调节细胞功能方面发挥着关键作用。在这些酶中，SIRT7 作为相对较晚发现和研究较少的成员脱颖而出。它定位于细胞核内，作为 NAD 依赖性脱乙酰酶发挥酶活性，靶向各种酰基基团。最近的多项研究记录了 SIRT7 在基因转录、细胞代谢、细胞应激反应和 DNA 损伤修复等重要细胞过程中的作用。这些研究还强调了 SIRT7 与人类疾病（如衰老、癌症、神经紊乱和心血管疾病）之间的强烈相关性。此外，已经报道了多种针对 SIRT7 的抑制剂，表明靶向 SIRT7 可能是抑制肿瘤生长的有前途的策略。本综述的目的是深入研究 SIRT7 的结构和功能，并探讨其在临床应用中的潜在价值，为相关领域的研究提供重要参考。
