Refining heart disease prediction accuracy using hybrid machine learning techniques with novel metaheuristic algorithms.

Early diagnosis of heart disease is crucial, as it's one of the leading causes of death globally. Machine learning algorithms can be a powerful tool in achieving this goal. Therefore, this article aims to increase the accuracy of predicting heart disease using machine learning algorithms. Five classification models are explored: eXtreme Gradient Boosting (XGBC), Random Forest Classifier (RFC), Decision Tree Classifier (DTC), K-Nearest Neighbors Classifier (KNNC), and Logistic Regression Classifier (LRC). Additionally, four optimizers are evaluated: Slime mold Optimization Algorithm, Forest Optimization Algorithm, Pathfinder algorithm, and Giant Armadillo Optimization. To ensure robust model selection, a feature selection technique utilizing k-fold cross-validation is employed. This method identifies the most relevant features from the data, potentially improving model performance. The top three performing models are then coupled with the optimization algorithms to potentially enhance their generalizability and accuracy in predicting heart failure. In the final stage, the shortlisted models (XGBC, RFC, and DTC) were assessed using performance metrics like accuracy, precision, recall, F1-score, and Matthews Correlation Coefficient (MCC). This rigorous evaluation identified the XGGA hybrid model as the top performer, demonstrating its effectiveness in predicting heart failure. XGGA achieved impressive metrics, with an accuracy, precision, recall, and F1-score of 0.972 in the training phase, underscoring its robustness. Notably, the model's predictions deviated by less than 5.5 % for patients classified as alive and by less than 1.2 % for those classified as deceased compared to the actual outcomes, reflecting minimal error and high predictive reliability. In contrast, the DTC base model was the least effective, with an accuracy of 0.840 and a precision of 0.847. Overall, the optimization using the GAO algorithm significantly enhanced the performance of the models, highlighting the benefits of this approach.