人类线粒体DNA的六个未鉴定阅读框编码呼吸链NADH脱氢酶的组分。
Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.
作者信息
Chomyn A, Mariottini P, Cleeter M W, Ragan C I, Matsuno-Yagi A, Hatefi Y, Doolittle R F, Attardi G
出版信息
Nature. 1985;314(6012):592-7. doi: 10.1038/314592a0.
The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NADH-K3Fe(CN)6 oxidoreductase activities. We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase.
针对高度纯化的天然牛心NADH-泛醌氧化还原酶（复合体I）的抗体，从线粒体裂解物中沉淀出人类线粒体DNA六个未鉴定阅读框的产物。这些产物在富含NADH-Q1和NADH-K3Fe(CN)6氧化还原酶活性的人类亚线粒体组分中大量富集。我们得出结论，这六个阅读框编码呼吸链NADH脱氢酶的组分。
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