College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, China; Key Laboratory of Agro-products Processing and Quality Safety of Heilongjiang Province, Daqing, China; National Coarse Cereals Engineering Research Center, Daqing, China.
College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, China.
Carbohydr Polym. 2024 Nov 15;344:122503. doi: 10.1016/j.carbpol.2024.122503. Epub 2024 Jul 19.
Konjac glucomannan (KGM) as an emerging natural polymer has attracted increasing interests owing to its film-forming properties, excellent gelation, non-toxic characteristics, strong adhesion, good biocompatibility, and easy biodegradability. Benefiting from these superior performances, KGM has been widely applied in the construction of multiple composite materials to further improve their intrinsic performances (e.g., mechanical strength and properties). Up to now, KGM-based composite materials have obtained widespread applications in diverse fields, especially in the field of biomedical. Therefore, a timely review of relevant research progresses is important for promoting the development of KGM-based composite materials. Innovatively, firstly, this review briefly introduced the structure properties and functions of KGMs based on the unique perspective of the biomedical field. Then, the latest advances on the preparation and properties of KGM-based composite materials (i.e., gels, microspheres, films, nanofibers, nanoparticles, etc.) were comprehensively summarized. Finally, the promising applications of KGM-based composite materials in the field of biomedical are comprehensively summarized and discussed, involving drug delivery, wound healing, tissue engineering, antibacterial, tumor treatment, etc. Impressively, the remaining challenges and opportunities in this promising field were put forward. This review can provide a reference for guiding and promoting the design and biomedical applications of KGM-based composites.
葡甘露聚糖（KGM）作为一种新兴的天然聚合物，由于其成膜性能、优异的凝胶化、无毒特性、强附着力、良好的生物相容性和易于生物降解性，引起了越来越多的关注。得益于这些卓越的性能，KGM 已广泛应用于多种复合材料的构建中，以进一步提高其内在性能（例如，机械强度和性能）。到目前为止，基于 KGM 的复合材料已经在多个领域得到了广泛的应用，特别是在生物医学领域。因此，及时审查相关研究进展对于促进基于 KGM 的复合材料的发展非常重要。创新性地，首先，本综述从生物医学领域的独特视角简要介绍了 KGM 的结构特性和功能。然后，全面总结了基于 KGM 的复合材料（即凝胶、微球、薄膜、纳米纤维、纳米粒子等）的制备和性能的最新进展。最后，全面总结和讨论了基于 KGM 的复合材料在生物医学领域的有前途的应用，涉及药物输送、伤口愈合、组织工程、抗菌、肿瘤治疗等。令人印象深刻的是，提出了该有前途领域中剩余的挑战和机遇。本综述可为指导和促进基于 KGM 的复合材料的设计和生物医学应用提供参考。
