Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, China.
Tissue Eng Regen Med. 2023 Dec;20(7):1017-1039. doi: 10.1007/s13770-023-00575-4. Epub 2023 Sep 9.
Cartilage, bone, and teeth, as the three primary hard tissues in the human body, have a significant application value in maintaining physical and mental health. Since the development of bacterial cellulose-based composite materials with excellent biomechanical strength and good biocompatibility, bacterial cellulose-based composites have been widely studied in hard tissue regenerative medicine. This paper provides an overview of the advantages of bacterial cellulose-based for hard tissue regeneration and reviews the recent progress in the preparation and research of bacterial cellulose-based composites in maxillofacial cartilage, dentistry, and bone.
A systematic review was performed by searching the PubMed and Web of Science databases using selected keywords and Medical Subject Headings search terms.
Ideal hard tissue regenerative medicine materials should be biocompatible, biodegradable, non-toxic, easy to use, and not burdensome to the human body; In addition, they should have good plasticity and processability and can be prepared into materials of different shapes; In addition, it should have good biological activity, promoting cell proliferation and regeneration. Bacterial cellulose materials have corresponding advantages and disadvantages due to their inherent properties. However, after being combined with other materials (natural/ synthetic materials) to form composite materials, they basically meet the requirements of hard tissue regenerative medicine materials. We believe that it is worth being widely promoted in clinical applications in the future.
Bacterial cellulose-based composites hold great promise for clinical applications in hard tissue engineering. However, there are still several challenges that need to be addressed. Further research is needed to incorporate multiple disciplines and advance biological tissue engineering techniques. By enhancing the adhesion of materials to osteoblasts, providing cell stress stimulation through materials, and introducing controlled release systems into matrix materials, the practical application of bacterial cellulose-based composites in clinical settings will become more feasible in the near future.
软骨、骨和牙齿是人体的三种主要硬组织，在维护身心健康方面具有重要的应用价值。自从开发出具有优异的生物力学强度和良好的生物相容性的细菌纤维素基复合材料以来，细菌纤维素基复合材料在硬组织再生医学中得到了广泛的研究。本文综述了细菌纤维素基复合材料在硬组织再生方面的优势，并综述了近年来在颌面软骨、牙科和骨组织中细菌纤维素基复合材料的制备和研究进展。
通过使用选定的关键词和医学主题词搜索词，在 PubMed 和 Web of Science 数据库中进行了系统综述。
理想的硬组织再生医学材料应具有生物相容性、可生物降解、无毒、使用方便、对人体无负担；此外，它们应具有良好的可塑性和可加工性，可以制备成不同形状的材料；此外，它应具有良好的生物活性，促进细胞增殖和再生。细菌纤维素材料由于其固有性质具有相应的优缺点。然而，在与其他材料（天然/合成材料）结合形成复合材料后，它们基本上满足硬组织再生医学材料的要求。我们相信，它们在未来的临床应用中值得广泛推广。
细菌纤维素基复合材料在硬组织工程临床应用中具有广阔的前景。然而，仍有几个挑战需要解决。需要进一步研究整合多个学科和推进生物组织工程技术。通过增强材料对成骨细胞的黏附性、通过材料提供细胞应力刺激、并将控制释放系统引入基质材料中，细菌纤维素基复合材料在临床应用中的实际应用在不久的将来将变得更加可行。
