Devilla L, Pende A, Morgano A, Giusti M, Musso N R, Lotti G
Neuroendocrinology. 1985 Apr;40(4):303-8. doi: 10.1159/000124091.
The effects of morphine (10 mg i.v.), an opioid agonist, and of naloxone (10 mg i.v.), an opioid antagonist, on serum levels of TSH and PRL were studied in 7 hypothyroid patients and in 5 normal volunteers. Morphine administration induced a prompt, significant increase in serum TSH and PRL in all subjects. The degree of PRL release after morphine was similar in the two groups, while, as regards TSH, the increase was more evident in hypothyroid subjects. Pretreatment with naloxone (4 mg i.v. 5 min before morphine administration) blocked these effects in all subjects. In contrast, naloxone alone was not able to affect significantly TSH and PRL secretion. Moreover, in 5 other euthyroid volunteers, morphine significantly enhanced the response of TSH and PRL to TRH stimulation (200 micrograms i.v.). These data demonstrate that morphine exerts a stimulatory action on TSH and PRL secretion: the possible mode of action of this drug and the physiologic significance of these findings are discussed.
在7名甲状腺功能减退患者和5名正常志愿者中研究了阿片类激动剂吗啡（静脉注射10毫克）和阿片类拮抗剂纳洛酮（静脉注射10毫克）对血清促甲状腺激素（TSH）和催乳素（PRL）水平的影响。给予吗啡后，所有受试者的血清TSH和PRL均迅速显著升高。两组中吗啡给药后PRL释放的程度相似，而关于TSH，甲状腺功能减退受试者的升高更为明显。在吗啡给药前5分钟静脉注射纳洛酮（4毫克）进行预处理可阻断所有受试者的这些效应。相比之下，单独使用纳洛酮不能显著影响TSH和PRL的分泌。此外，在另外5名甲状腺功能正常的志愿者中，吗啡显著增强了TSH和PRL对促甲状腺激素释放激素（TRH，静脉注射200微克）刺激的反应。这些数据表明，吗啡对TSH和PRL的分泌具有刺激作用：本文讨论了该药物可能的作用方式以及这些发现的生理学意义。
