• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

钙调神经磷酸酶 3 调节剂作为一种新型泛癌诊断和预后标志物。

Regulator of calcineurin 3 as a novel predictor of diagnosis and prognosis in pan-cancer.

机构信息

Wenle Li, Department of Gynecology, Affiliated Hospital of Guangdong Medical University, No. 57, Renmin Avenue South, Xiashan District, Zhanjiang, Guangdong, 524000, China,

出版信息

Croat Med J. 2024 Aug 31;65(4):356-372. doi: 10.3325/cmj.2024.65.356.

DOI:10.3325/cmj.2024.65.356
PMID:39219199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11399725/
Abstract

AIM

To assess diagnostic and prognostic value of regulator of calcineurin 3 (RCAN3) in various malignancies.

METHODS

RCAN3 expression levels were assessed across pan-cancer data sets including various molecular and immune subtypes. Receiver operating characteristic (ROC) and Kaplan-Meier curves were employed to determine the diagnostic and prognostic value of RCAN3 in pan-cancer, respectively. Enrichment analyses were used to identify RCAN3-associated terms and pathways. A special focus was placed on cervical squamous cell carcinoma and endocervical adenocarcinoma cervical cancer (CESC); we assessed the prognostic value of RCAN expression within distinct clinical subgroups and its effect on m6A modifications and immune infiltration.

RESULTS

RCAN3 expression varied not only in different cancer types but also in different molecular and immune subtypes of cancers. RCAN3 displayed high accuracy in diagnosing and predicting cancers, and RCAN3 expression level was associated with the prognosis of certain cancers. CESC patients with a high RCAN3 level had a worse overall survival, disease-specific survival, and progression-free interval. RCAN3 expression was related to multiple m6A modifier genes and immune cells.

CONCLUSION

In general, RCAN3 can serve as a novel biomarker for the diagnosis and prognosis in pan-cancer, especially in CESC. It may represent a promising molecular target for developing new treatments. However, our analysis is limited to bioinformatic predictions, and further biological experiments are necessary to verify our results.

摘要

目的

评估钙调神经磷酸酶调节剂 3（RCAN3）在多种恶性肿瘤中的诊断和预后价值。

方法

评估了 RCAN3 在包括各种分子和免疫亚型的泛癌症数据集中的表达水平。使用接收者操作特征（ROC）和 Kaplan-Meier 曲线分别确定 RCAN3 在泛癌症中的诊断和预后价值。富集分析用于确定与 RCAN3 相关的术语和途径。特别关注宫颈鳞状细胞癌和宫颈内膜腺癌（CESC）；我们评估了 RCAN 表达在不同临床亚组中的预后价值及其对 m6A 修饰和免疫浸润的影响。

结果

RCAN3 的表达不仅在不同的癌症类型中有所不同，而且在不同的分子和免疫亚型的癌症中也有所不同。RCAN3 在诊断和预测癌症方面具有很高的准确性，RCAN3 的表达水平与某些癌症的预后相关。RCAN3 水平较高的 CESC 患者的总生存期、疾病特异性生存期和无进展生存期更差。RCAN3 表达与多种 m6A 修饰基因和免疫细胞有关。

结论

总的来说，RCAN3 可以作为泛癌症诊断和预后的新型生物标志物，尤其是在 CESC 中。它可能代表着开发新治疗方法的有前途的分子靶标。然而，我们的分析仅限于生物信息学预测，需要进一步的生物学实验来验证我们的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/354ab32adef6/CroatMedJ_65_0356-F12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/8c315ac1d355/CroatMedJ_65_0356-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/4b4856f1b377/CroatMedJ_65_0356-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/3cc48eac0a2e/CroatMedJ_65_0356-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/5de5ad72f4d3/CroatMedJ_65_0356-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/cc29ff0cb276/CroatMedJ_65_0356-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/182f67e3c1d3/CroatMedJ_65_0356-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/a282795a8ace/CroatMedJ_65_0356-F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/d13a6f67ace4/CroatMedJ_65_0356-F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/2c40f4b5a96c/CroatMedJ_65_0356-F9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/73334f66d1ae/CroatMedJ_65_0356-F10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/4aa1ed29d665/CroatMedJ_65_0356-F11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/354ab32adef6/CroatMedJ_65_0356-F12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/8c315ac1d355/CroatMedJ_65_0356-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/4b4856f1b377/CroatMedJ_65_0356-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/3cc48eac0a2e/CroatMedJ_65_0356-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/5de5ad72f4d3/CroatMedJ_65_0356-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/cc29ff0cb276/CroatMedJ_65_0356-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/182f67e3c1d3/CroatMedJ_65_0356-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/a282795a8ace/CroatMedJ_65_0356-F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/d13a6f67ace4/CroatMedJ_65_0356-F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/2c40f4b5a96c/CroatMedJ_65_0356-F9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/73334f66d1ae/CroatMedJ_65_0356-F10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/4aa1ed29d665/CroatMedJ_65_0356-F11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2392/11399725/354ab32adef6/CroatMedJ_65_0356-F12.jpg

相似文献

1
Regulator of calcineurin 3 as a novel predictor of diagnosis and prognosis in pan-cancer.钙调神经磷酸酶 3 调节剂作为一种新型泛癌诊断和预后标志物。
Croat Med J. 2024 Aug 31;65(4):356-372. doi: 10.3325/cmj.2024.65.356.
2
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification.ZNF695，一种潜在的预后生物标志物，与宫颈鳞癌和宫颈内膜腺癌中的免疫浸润相关：生物信息学分析和实验验证。
Curr Gene Ther. 2024;24(5):441-452. doi: 10.2174/0115665232285216240228071244.
3
A prognostic signature based on immune-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma.一种基于免疫相关基因的子宫颈鳞状细胞癌和子宫颈管腺癌预后标志物。
Int Immunopharmacol. 2020 Nov;88:106884. doi: 10.1016/j.intimp.2020.106884. Epub 2020 Aug 11.
4
Down-regulation of S1PR2 is correlated with poor prognosis and immune infiltrates in cervical squamous cell carcinoma and endocervical adenocarcinoma.S1PR2 的下调与宫颈鳞癌和宫颈内膜腺癌的不良预后和免疫浸润有关。
Int J Immunopathol Pharmacol. 2023 Jan-Dec;37:3946320231178131. doi: 10.1177/03946320231178131.
5
SQLE-a promising prognostic biomarker in cervical cancer: implications for tumor malignant behavior, cholesterol synthesis, epithelial-mesenchymal transition, and immune infiltration.SQLE 是宫颈癌有前途的预后生物标志物：对肿瘤恶性行为、胆固醇合成、上皮-间充质转化和免疫浸润的影响。
BMC Cancer. 2024 Sep 11;24(1):1133. doi: 10.1186/s12885-024-12897-0.
6
A Novel Prognostic Risk Model for Cervical Cancer Based on Immune Checkpoint HLA-G-Driven Differentially Expressed Genes.基于免疫检查点 HLA-G 驱动的差异表达基因的宫颈癌新型预后风险模型。
Front Immunol. 2022 Jul 18;13:851622. doi: 10.3389/fimmu.2022.851622. eCollection 2022.
7
Expressions of m6A RNA methylation regulators and their clinical predictive value in cervical squamous cell carcinoma and endometrial adenocarcinoma.m6A RNA 甲基化调控因子的表达及其在宫颈鳞癌和子宫内膜腺癌中的临床预测价值。
Clin Exp Pharmacol Physiol. 2021 Feb;48(2):270-278. doi: 10.1111/1440-1681.13412. Epub 2020 Oct 21.
8
Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification.鉴定与宫颈癌肿瘤免疫微环境相关的坏死性凋亡相关预后基因特征，并进行实验验证。
World J Surg Oncol. 2022 Oct 17;20(1):342. doi: 10.1186/s12957-022-02802-z.
9
Pan-Cancer Analysis of Immune Cell Infiltration Identifies a Prognostic Immune-Cell Characteristic Score (ICCS) in Lung Adenocarcinoma.泛癌症分析免疫细胞浸润鉴定出肺腺癌预后免疫细胞特征评分（ICCS）。
Front Immunol. 2020 Jun 30;11:1218. doi: 10.3389/fimmu.2020.01218. eCollection 2020.
10
Functional implications of miR-145/RCAN3 axis in the progression of cervical cancer.miR-145/RCAN3 轴在宫颈癌进展中的功能意义。
Reprod Biol. 2020 Jun;20(2):140-146. doi: 10.1016/j.repbio.2020.04.001. Epub 2020 Apr 25.

引用本文的文献

1
N6-methyladenosine in cervical carcinogenesis: Mechanistic insights and therapeutic perspectives (Review).N6-甲基腺苷在宫颈癌发生中的作用机制及治疗前景（综述）
Oncol Lett. 2025 Jul 14;30(3):442. doi: 10.3892/ol.2025.15188. eCollection 2025 Sep.

本文引用的文献

1
RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium.RCAN 家族成员 3 缺乏导致心室心肌致密化不全。
J Genet Genomics. 2024 May;51(5):543-553. doi: 10.1016/j.jgg.2023.12.010. Epub 2024 Jan 3.
2
CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma.环状 RNA IQGAP1 通过 ceRNA 机制调控 RCAN1 和 RCAN2 并促进恶性脑胶质瘤的生长。
Pharmacol Res. 2023 Nov;197:106979. doi: 10.1016/j.phrs.2023.106979. Epub 2023 Oct 31.
3
RCAN1-mediated calcineurin inhibition as a target for cancer therapy.
RCAN1 介导体细胞钙调神经磷酸酶抑制作为癌症治疗的靶点。
Mol Med. 2022 Jun 18;28(1):69. doi: 10.1186/s10020-022-00492-7.
4
Calcineurin in development and disease.发育与疾病中的钙调神经磷酸酶
Genes Dis. 2021 Mar 15;9(4):915-927. doi: 10.1016/j.gendis.2021.03.002. eCollection 2022 Jul.
5
N-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification.N6-甲基腺苷甲基转移酶 METTL3 通过 YTHDF1/HK2 修饰促进宫颈癌肿瘤发生和瓦博格效应。
Cell Death Dis. 2020 Oct 24;11(10):911. doi: 10.1038/s41419-020-03071-y.
6
Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region.钙调神经磷酸酶调节剂（RCAN）：超越唐氏综合征关键区域。
Mol Cells. 2020 Aug 31;43(8):671-685. doi: 10.14348/molcells.2020.0060.
7
Functional implications of miR-145/RCAN3 axis in the progression of cervical cancer.miR-145/RCAN3 轴在宫颈癌进展中的功能意义。
Reprod Biol. 2020 Jun;20(2):140-146. doi: 10.1016/j.repbio.2020.04.001. Epub 2020 Apr 25.
8
mA in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2.mRNA 编码区中的 mA 通过含有 RNA 解旋酶的 YTHDC2 促进翻译。
Nat Commun. 2019 Nov 25;10(1):5332. doi: 10.1038/s41467-019-13317-9.
9
mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation.mA 修饰通过调节 HINT2 mRNA 翻译抑制眼黑色素瘤。
Mol Cancer. 2019 Nov 14;18(1):161. doi: 10.1186/s12943-019-1088-x.
10
Molecular characterization and clinical relevance of mA regulators across 33 cancer types.跨越 33 种癌症类型的 mA 调节剂的分子特征和临床相关性。
Mol Cancer. 2019 Sep 14;18(1):137. doi: 10.1186/s12943-019-1066-3.