人脱铁转铁蛋白输注治疗中间型β地中海贫血患者的安全性和有效性：AIM研究 - Suppr

Safety and efficacy of human apotransferrin infusion in patients with β-thalassemia intermedia: the AIM study.

作者信息

Konté Kadère, Swinkels Dorine W, Budde Ilona Kleine, Nur Erfan, Biemond Bart J

机构信息

Department of Clinical Hematology, Amsterdam University Medical Centres, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam.

Department of Laboratory Medicine, Radboud University medical Centre, Nijmegen, The Netherlands, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands; Sanquin Blood Bank and Sanquin Diagnostics BV, Plesmanlaan 125, 1066 CX Amsterdam.

出版信息

Haematologica. 2025 Jan 1;110(1):183-186. doi: 10.3324/haematol.2024.285045.

DOI:10.3324/haematol.2024.285045

PMID:39219461

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11694103/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/557b/11694103/7affd3a6014c/110183.fig1.jpg

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Safety and efficacy of human apotransferrin infusion in patients with β-thalassemia intermedia: the AIM study.人脱铁转铁蛋白输注治疗中间型β地中海贫血患者的安全性和有效性：AIM研究

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Rare double heterozygosity for poly A(A〉 G) and CD17(A〉 T) of beta thalassemia intermedia in a Chinese family.一个中国家庭中罕见的中间型β地中海贫血的聚腺苷酸（A＞G）和CD17（A＞T）双杂合性。

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Hematol Oncol Clin North Am. 2023 Apr;37(2):313-325. doi: 10.1016/j.hoc.2022.12.003.

Non-transferrin-bound iron transporters.非转铁蛋白结合铁转运体。

Free Radic Biol Med. 2019 Mar;133:101-111. doi: 10.1016/j.freeradbiomed.2018.10.413. Epub 2018 Oct 12.

Iron overload in thalassemia: different organs at different rates.地中海贫血中的铁过载：不同器官以不同的速度发生。

Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):265-271. doi: 10.1182/asheducation-2017.1.265.

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.脱铁转铁蛋白对未输血和已输血的Hbbth3/+（杂合B1/B2珠蛋白基因缺失）小鼠血色素沉着症的逆转作用。

Haematologica. 2015 May;100(5):611-22. doi: 10.3324/haematol.2014.117325. Epub 2015 Jan 23.

Beta-thalassemia.β-地中海贫血。

Orphanet J Rare Dis. 2010 May 21;5:11. doi: 10.1186/1750-1172-5-11.

Transferrin therapy ameliorates disease in beta-thalassemic mice.转铁蛋白治疗可改善β-地中海贫血小鼠的疾病。

Nat Med. 2010 Feb;16(2):177-82. doi: 10.1038/nm.2073. Epub 2010 Jan 24.

Effect of repeated apotransferrin administrations on serum iron parameters in patients undergoing myeloablative conditioning and allogeneic stem cell transplantation.多次给予脱铁转铁蛋白对接受清髓性预处理和异基因干细胞移植患者血清铁参数的影响。

Br J Haematol. 2006 Oct;135(2):228-34. doi: 10.1111/j.1365-2141.2006.06273.x. Epub 2006 Aug 22.

Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection.鉴定小鼠乳腺肿瘤病毒感染所需的小鼠转铁蛋白受体1的片段。

J Biol Chem. 2006 Apr 14;281(15):10243-9. doi: 10.1074/jbc.M511572200. Epub 2006 Feb 15.

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Br J Haematol. 2002 Nov;119(2):547-53. doi: 10.1046/j.1365-2141.2002.03836.x.

Transferrin: physiologic behavior and clinical implications.转铁蛋白：生理行为及临床意义。

Blood. 1984 Oct;64(4):763-7.

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Safety and efficacy of human apotransferrin infusion in patients with β-thalassemia intermedia: the AIM study.

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