Goldstein J, Thoua Y, Wellens F, Leclerc J L, Vanherweghem J L, Vereerstraeten P, Primo G, Toussaint C
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:973-81.
Cyclosporine nephrotoxicity after heart transplantation can lead to acute renal failure requiring haemodialysis. In four long-term heart-transplant survivors, cyclosporine nephropathy was characterised by extensive fibrosis, with uraemia, hypertension and/or anaemia. In contrast, the long-term survivor of heart-lung transplantation who had received her graft for accelerated respiratory failure, did not develop chronic renal disease. Thus, chronically reduced renal perfusion before heart transplantation may play a critical role in the development of chronic cyclosporine nephropathy.
心脏移植后环孢素肾毒性可导致急性肾衰竭，需要进行血液透析。在4名心脏移植长期存活者中，环孢素肾病的特征是广泛纤维化，并伴有尿毒症、高血压和/或贫血。相比之下，因呼吸功能衰竭加速而接受心肺移植的长期存活者并未发生慢性肾病。因此，心脏移植前长期肾灌注减少可能在慢性环孢素肾病的发生中起关键作用。
