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本文引用的文献

1
Safety and risk assessment of psychedelic psychotherapy: A meta-analysis and systematic review.迷幻心理治疗的安全性与风险评估:一项荟萃分析与系统评价
Psychiatry Res. 2024 May;335:115880. doi: 10.1016/j.psychres.2024.115880. Epub 2024 Mar 31.
2
Acceptability of psilocybin-assisted group therapy in patients with cancer and major depressive disorder: Qualitative analysis.接受度评估:迷幻蘑菇辅助团体治疗癌症合并重度抑郁障碍患者的疗效:定性分析。
Cancer. 2024 Apr 1;130(7):1147-1157. doi: 10.1002/cncr.35024. Epub 2023 Dec 18.
3
Can psychedelics enhance group psychotherapy? A discussion on the therapeutic factors.迷幻药能增强团体心理治疗吗?对治疗因素的探讨。
J Psychopharmacol. 2023 Jul;37(7):660-678. doi: 10.1177/02698811231155117. Epub 2023 Feb 28.
4
Lower-dose psycholytic therapy - A neglected approach.低剂量精神olytic疗法——一种被忽视的方法。 (注:原文中“psycholytic”可能有误,推测正确的词可能是“psycholytic”,但按给定原文准确翻译如此)
Front Psychiatry. 2022 Dec 2;13:1020505. doi: 10.3389/fpsyt.2022.1020505. eCollection 2022.
5
Lysergic Acid Diethylamide-Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study.伴或不伴威胁生命疾病的焦虑症患者中麦角酸二乙酰胺辅助治疗的随机、双盲、安慰剂对照 II 期研究。
Biol Psychiatry. 2023 Feb 1;93(3):215-223. doi: 10.1016/j.biopsych.2022.08.025. Epub 2022 Sep 5.
6
Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial.裸盖菇素辅助心理治疗与安慰剂治疗酒精使用障碍成年患者后重度饮酒日的百分比:一项随机临床试验。
JAMA Psychiatry. 2022 Oct 1;79(10):953-962. doi: 10.1001/jamapsychiatry.2022.2096.
7
Psychedelic-assisted psychotherapy to treat psychiatric and existential distress in life-threatening medical illnesses and palliative care.致幻剂辅助心理治疗在危及生命的疾病和姑息治疗中治疗精神和存在性痛苦。
Neuropharmacology. 2022 Sep 15;216:109174. doi: 10.1016/j.neuropharm.2022.109174. Epub 2022 Jun 27.
8
Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders.在瑞士的临床实践中采用摇头丸和麦角酸二乙酰胺团体治疗模式并强调创伤相关障碍的治疗
Front Psychiatry. 2022 Apr 25;13:863552. doi: 10.3389/fpsyt.2022.863552. eCollection 2022.
9
Toward Risk-Benefit Assessments in Psychedelic- and MDMA-Assisted Therapies.迈向迷幻剂和摇头丸辅助疗法的风险效益评估。
JAMA Psychiatry. 2022 Jun 1;79(6):525-527. doi: 10.1001/jamapsychiatry.2022.0665.
10
Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up.辅助使用裸盖菇素治疗重度抑郁症的疗效和安全性:前瞻性 12 个月随访。
J Psychopharmacol. 2022 Feb;36(2):151-158. doi: 10.1177/02698811211073759.

居家治疗环境中用于姑息治疗的迷幻剂辅助疗法:一例报告

Psychedelic-assisted therapy for palliative care within a home treatment setting: A case report.

作者信息

Federico Seragnoli, Geo Martignoni, Entela Martignoni, Bachmann Silke, Elisa Rabitti, Silvio Cavuto, Zoë Dubus, Louise Penzenstadler, Gabriel Thorens, Joël Billieux, Daniele Zullino

机构信息

Psychiatry Department Geneva University Hospitals Geneva Switzerland.

Institute of Psychology University of Lausanne Lausanne Switzerland.

出版信息

Clin Case Rep. 2024 Aug 30;12(9):e9305. doi: 10.1002/ccr3.9305. eCollection 2024 Sep.

DOI:10.1002/ccr3.9305
PMID:39219779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11364487/
Abstract

KEY CLINICAL MESSAGE

This case study describes the feasibility and safety of psychedelic-assisted therapy (PAT) as a home-based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well. This case supports the feasibility and safety of PAT for patients with life-threatening conditions in a home setting.

ABSTRACT

Psychedelic-assisted therapy (PAT), as it is practiced today, merges traditional psychotherapeutic techniques with the use of psychedelics such as LSD, psilocybin, or MDMA with the aim of unlocking deeper insights in patients and treating mental conditions that are resistant to other forms of therapy. The present case study describes the safety of PAT as a home-based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well and was asked to report on measures of anxiety, depression, and distress related to his somatic condition. The observations provided by this clinical case report align with previous findings, suggesting that PAT can be safely applied to potentially provide relief from existential distress in patients with life-threatening conditions. As this is a single-case study, generalizations should be made cautiously. Moreover, placebo effects, expectancy effects, and the natural course of the disease may influence outcomes. Future research should consider controlled trials to ascertain the efficacy and safety of such interventions in diverse settings.

摘要

关键临床信息

本案例研究描述了迷幻辅助疗法(PAT)作为一种居家干预措施,用于治疗一名患有喉癌且存在严重生存困扰患者的可行性和安全性。该患者对干预耐受良好。此案例支持了PAT在居家环境中用于患有危及生命疾病患者的可行性和安全性。

摘要

当今所实施的迷幻辅助疗法(PAT)将传统心理治疗技术与使用诸如麦角酸二乙酰胺(LSD)、裸盖菇素或摇头丸等迷幻剂相结合,旨在使患者获得更深刻的领悟,并治疗对其他形式治疗有抵抗性的精神疾病。本案例研究描述了PAT作为一种居家干预措施,用于治疗一名患有喉癌且存在严重生存困扰患者的安全性。该患者对干预耐受良好,并被要求报告与他躯体状况相关的焦虑、抑郁和困扰程度的指标。这份临床病例报告所提供的观察结果与先前的研究结果一致,表明PAT可以安全应用,有可能缓解患有危及生命疾病患者的生存困扰。由于这是一项单病例研究,应谨慎进行归纳总结。此外,安慰剂效应、期望效应以及疾病的自然病程可能会影响结果。未来的研究应考虑进行对照试验,以确定此类干预措施在不同环境中的疗效和安全性。