Schardein J L
Prog Clin Biol Res. 1985;163C:181-90.
The facts demonstrate conclusively that ingestion of certain drugs during pregnancy can induce adverse effects in the unborn child. However, few new teratogens or epidemics of birth defects have been identified since the thalidomide disaster, which attests both to effective laboratory testing of drugs in animals prior to clinical use and the extensive surveillance of use of new therapeutic agents in women during pregnancy. It is clear that these practices should continue in order to protect the pregnant woman and her conceptus, and benefits and risks should be carefully weighed before administration of a drug during pregnancy.
事实确凿地表明，孕期摄入某些药物会对胎儿产生不良影响。然而，自沙利度胺灾难以来，几乎没有发现新的致畸物或出生缺陷流行情况，这既证明了临床使用前对药物进行有效的动物实验室检测，也证明了对孕期妇女使用新治疗药物进行广泛监测。显然，这些做法应继续下去，以保护孕妇及其胎儿，并且在孕期给药前应仔细权衡利弊。
